phospho-GABBR2 (Ser884)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy- 13258R
英文名称phospho-GABBR2 (Ser884)
中文名称磷酸化G氨基丁酸B型受体2抗体
别 名GABA B Receptor 2 (phospho S884); p-GABA B Receptor 2 (phospho S884); p-GABBR2 (Ser884) ; GABBR2; GB2; G protein coupled receptor 51; G-protein coupled receptor 51; GAB B R2; GABA B R2; GABA B receptor 2; GABA B RECEPTOR; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABA[[B]]R2; GABAB R2; GABABR 2; GABABR2; GABB R2; GABBR 2; Gabbr2; GABR2_HUMAN; Gamma aminobutyric acid (GABA) B receptor 2; Gamma aminobutyric acid B receptor 2; Gamma aminobutyric acid GABA B receptor 2; Gamma aminobutyric acid type B receptor subunit 2; Gamma-aminobutyric acid type B receptor subunit 2; Gb 2; Gb2; GH07312; GPR 51; GPR51; GPRC 3B; GPRC3B; HG 20; HG20; HRIHFB2099; Metabotropic GABA B receptor subtype 2; OTTHUMP00000021776; OTTHUMP00000063797; R2 SUBUNIT; BcDNA:GH07312; CG6706; CT20836; D GABA[[B]]R2; D Gaba2; FLJ36928.
说 明 书100ul
产品类型磷酸化抗体
研究领域细胞生物 神经生物学 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
phospho-GABBR2 (Ser884)抗体交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量104kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human GABBR2 around the phosphorylation site of Ser884:IN(p-S)PE
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
phospho-GABBR2 (Ser884)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].
Function:
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Subunit:
Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.
Subcellular Location:
ell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.
Tissue Specificity:
Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.
Similarity:
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
SWISS:
O75899
Gene ID:
9568
Database links:
UniProtKB/Swiss-Prot: O75899.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
phospho-GABBR2 (Ser884)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
phospho-GABBR2 (Ser884)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 NMDAR2B 谷氨酸受体2B抗体
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合格 Phospho-PDGFRA(Tyr849)/PDGFRB(Tyr857) 磷酸化血小板源性生长因子受体α/β抗体
合格 Phospho-PBK (Thr9) 磷酸化PDZ连接激酶/T-LAK细胞源蛋白激酶抗体
合格 合格 Phospho-PDK1(Ser241) 磷酸化3磷酸肌醇依赖性蛋白激酶1
合格 Phospho-PERK(Thr980) 磷酸化蛋白激酶样内质网激酶抗体
合格 合格 phospho-PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199) 磷酸化磷脂酰肌醇激酶/PI3 Kinase P85α/γ抗体
合格 合格 Phospho-PKR (Thr451) 磷酸化蛋白激酶R抗体
合格 Phospho-PKR (Thr446 + Thr451) 磷酸化蛋白激酶R抗体
合格 合格 Phospho-PLCG 2 (Tyr1217) 磷酸化磷酯酶Cγ2抗体
合格 合格 Phospho-PLC beta3 (Ser1105) 磷酸化磷酯酶Cβ3抗体
合格 Phospho-PLC gamma 1(Ser1248) 磷酸化磷酯酶Cγ1抗体
合格 Phospho-PLC gamma 1 (Tyr783) 磷酸化磷酯酶Cγ1抗体
合格 Phospho-PLK1 (Ser137) 磷酸化丝/苏氨酸蛋白激酶Plk1抗体
合格 Phospho-PSD95 (Tyr236 + Tyr240) 磷酸化突触后密度蛋白95抗体
合格 合格 Phospho-PTEN(Ser380 + Thr382 + Thr383) 磷酸化肿瘤抑制基因PTEN抗体
合格 Phospho-Pin1 (Ser16) 磷酸化肽基脯氨酞顺反异构酶Pinl抗体
合格 Phospho-Progesterone Receptor(Ser190) 磷酸化孕**受体抗体
合格 Phospho-RPS6KA1 (Thr359 + Ser363) 磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体
合格 Phospho-RPS6KA1 (Thr573) 磷酸化丝氨酸/苏氨酸激酶p90RSK蛋白抗体
合格 phospho-c-Raf (Ser289) 磷酸化原癌基因c-Raf抗体
合格 Phospho-RASGRF1 (Ser916) 磷酸化Ras特异性鸟嘌呤核苷酸释放因子1
合格 Phospho-RPS6 (Ser235+Ser236) 磷酸化S6核糖体蛋白抗体
合格 Phospho-MEK4 (Ser257 + Thr261) 磷酸化丝裂原活化蛋白激酶激酶4抗体
合格 合格 Phospho-SGK1 (Ser422) 磷酸化糖皮质**调节激酶1抗体
合格 Phospho-INPPL1(Tyr1135) 磷酸化肌醇聚磷酸盐磷酸酶样蛋白1抗体