phospho-KAT5 (Ser90)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy- 17097R
英文名称phospho-KAT5 (Ser90)
中文名称磷酸化组蛋白乙酰转移酶KAT5抗体
别 名KAT5 / Tip60 (phospho S90); p-KAT5 / Tip60 (phospho S90); 60 kDa Tat interactive protein; 60 kDa Tat-interactive protein; cPLA(2) interacting protein; cPLA(2)-interacting protein; cPLA2; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV 1 Tat interactive protein; HIV 1 Tat interactive protein, 60kDa; HIV-1 Tat interactive protein; HTATIP; HTATIP1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; KAT5; KAT5_HUMAN; Lysine acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; TIP; Tip60.
说 明 书100ul
产品类型磷酸化抗体
研究领域细胞生物 **学 信号转导 转录调节因子 新陈代谢 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
phospho-KAT5 (Ser90)抗体交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量59kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human KAT5 around the phosphorylation site of Ser90:51-150/513
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
phospho-KAT5 (Ser90)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Function:
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
Subcellular Location:
Nucleus > nucleolus. Cytoplasm > perinuclear region. Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.
Post-translational modifications:
Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies.
Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase.
Phosphorylated form has a higher activity.
Ubiquitinated by MDM2, leading to its proteasome-dependent degradation.
Similarity:
Belongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
SWISS:
Q92993
Gene ID:
10524
phospho-KAT5 (Ser90)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
phospho-KAT5 (Ser90)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 合格 phospho-beta Catenin (Thr41) 磷酸化β-连环蛋白/β-连环素/β链接素抗体
合格 phospho-beta Catenin (Tyr333) 磷酸化β-连环蛋白/β-连环素/β链接素抗体
合格 phospho-beta Catenin (Tyr489) 磷酸化β-连环蛋白/β-连环素/β链接素抗体
合格 ETS1 转录因子家族ETS1抗体
合格 Beta crystallin S γS-crystallin蛋白抗体
合格 beta IV Tubulin 微管蛋白β4抗体
合格 合格 TUBB5 微管蛋白β5抗体
合格 phospho-Bid (Ser78) 磷酸化BH3结构域凋亡诱导蛋白抗体
合格 合格 NR1H4 胆汁酸受体抗体
合格 合格 Biliverdin Reductase 胆绿素还原酶抗体
合格 CD40L CD40L抗体
合格 phospho-BNIP3 (Ser95) 磷酸化促凋亡调节蛋白BNIP3抗体
合格 合格 IKB alpha 核因子κB抑制蛋白α抗体
合格 BRAF35 乳腺癌易感基因2相关蛋白抗体
合格 BRD2 BRD2蛋白抗体
合格 GDF8 生长分化因子8抗体
合格 phospho-Brk (Tyr447) 磷酸化酪氨酸蛋白激酶6/乳腺肿瘤激酶抗体
合格 TCF7L1 转录因子7样蛋白1抗体
合格 TADA3L TADA3L蛋白抗体
合格 合格 TAF1A TATA盒结合蛋白相关因子TAF1A抗体
合格 BSX 脑特异性同源蛋白BSX抗体
合格 BTN2A1 + BTN2A2 嗜乳脂蛋白2亚型A1抗体
合格 CCN1 富半胱氨酸肝素结合蛋白61抗体
合格 Phospho-c-Fos (Ser374) 磷酸化c-fos抗体
合格 phospho-c-Jun(Thr93) 磷酸化原癌基因c-Jun抗体
合格 合格 Phospho-c-Kit (Tyr730) 磷酸化原癌基因c-kit抗体
合格 phospho-c-Kit(Tyr823) 磷酸化原癌基因c-kit抗体
合格 phospho-c-Kit(Tyr568 + Tyr570) 磷酸化原癌基因c-kit抗体
合格 合格 phospho-Cytokeratin 8 (Ser431) 磷酸化细胞角蛋白8抗体
合格 phospho-CK18(Ser52) 磷酸化细胞角蛋白18抗体