Phospho-NMDAR1 (Ser897)抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy- 3903R
英文名称Phospho-NMDAR1 (Ser897)
中文名称磷酸化离子型谷氨酸受体1抗体
别 名NMDAR1 (phospho S897); p-NMDAR1 (phospho S897); NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN.
说 明 书100ul
产品类型磷酸化抗体
研究领域细胞生物 **学 神经生物学 信号转导 转录调节因子 激酶和磷酸酶 细胞膜受体 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
Phospho-NMDAR1 (Ser897)抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow,
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量103kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser897:851-938/938 <Cytoplasmic>
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Phospho-NMDAR1 (Ser897)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Subunit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with MYZAP.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
Post-translational modifications:
NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.
DISEASE:
Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
SWISS:
Q05586
Gene ID:
2902
Phospho-NMDAR1 (Ser897)抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
Phospho-NMDAR1 (Ser897)抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 B MyB 转录因子MYB相关蛋白B抗体
合格 合格 NARG2 谷氨酸受体调节蛋白2抗体
合格 PLAG1 多型性腺瘤基因1蛋白抗体
合格 SIRT7 沉默调节样蛋白SirT7抗体
合格 合格 AARE 氧化蛋白质水解酶
合格 DAB2IP Dab2相互作用蛋白抗体
合格 DAB2 信号转导功能磷蛋白DAB2抗体
合格 HSP40 热休克蛋白家族40抗体
合格 DAL1/EPB41L3 细胞骨架4.1蛋白家族DAL1抗体
合格 FBXO31 F-box蛋白家族FBXO31抗体
合格 合格 ASAM 脂肪细胞特异性粘附分子抗体
合格 BST1 骨髓基质干细胞抗原1抗体
合格 TSLC1 细胞粘附分子1抗体
合格 CD16 FC段γ受体3/**球蛋白G Fc段受体III抗体
合格 合格 phospho-CD32B(Tyr292) 磷酸化CD32B抗体
合格 CPA1 胰羧肽酶A1抗体
合格 Protective protein/Cathepsin A 组织蛋白酶A抗体
合格 Ephrin A3 酪氨酸蛋白激酶A3受体抗体
合格 Prostaglandin dehydrogenase 1 前列腺素脱氢酶1抗体
合格 METTL11A 甲基化样蛋白11抗体（N端）
合格 IGFBP9 胰岛素样生长因子结合蛋白9抗体
合格 PRMT6 组蛋白精氨酸甲基转移酶6抗体
合格 TCF3 转录因子3抗体（螺旋环螺旋蛋白HE47）
合格 MFSD2A 促进调解蛋白家族2A抗体
合格 RASAL1 RAS蛋白样激活剂1抗体