POMC抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy- 6942R
英文名称POMC
中文名称阿黑皮素原抗体
别 名ACTH; Adrenocorticotropic hormone; Adrenocorticotropin; Adrenocorticotropin Hormone; Alpha Melanocyte Stimulating Hormone; Alpha MSH; Alpha-MSH; Beta Endorphin; Beta Lipotropin; Beta LPH; Beta Melanocyte Stimulating Hormone; Beta MSH; Beta-LPH; Beta-MSH; CLIP; COLI_HUMAN; Corticotropin Like Intermediary Peptide; Corticotropin lipotropin; Corticotropin lipotropin precursor; Corticotropin-lipotropin; Gamma MSH; Gamma-LPH; Gamma-MSH; Lipotropin Beta; Lipotropin Gamma; LPH; Melanotropin Alpha; Melanotropin; Melanotropin beta; Melanotropin gamma; Met Enkephalin; Met-enkephalin; MSH; NPP; POC; POMC; pro ACTH endorphin; Pro opiomelanocortin; Proopiomelanocortin; Proopiomelanocortin preproprotein.
说 明 书100ul 200ul
研究领域肿瘤 细胞生物 神经生物学 信号转导 ***病
抗体来源Rabbit
克隆类型Polyclonal
POMC抗体交叉反应 Human, Mouse, Rat, Cow, Sheep,
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human POMC:27-102/267 23
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
POMC抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Function:
ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.
Subcellular Location:
Secreted.
Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.
Post-translational modifications:
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
DISEASE:
Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.
Similarity:
Belongs to the POMC family.
SWISS:
P01189
Gene ID:
5443
POMC抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
POMC抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 VGLL3 转录辅助因子退变样蛋白3抗体
合格 合格 PTPH1 蛋白酪氨酸磷酸酶H1抗体
合格 合格 MLT5 睾丸特异性MLT5蛋白抗体
合格 CD101 CD101抗体
合格 合格 IGSF9 **球蛋白超家族成员9抗体
合格 IGSF11 大脑和睾丸特异性**球蛋白超家族成员11抗体
合格 IGSF12 **球蛋白超家族成员12抗体
合格 合格 IGSF21 **球蛋白超家族成员21抗体
合格 GDE3 促进成骨细胞分化因子/GDPD2抗体
合格 SERPINB11 丝氨酸蛋白酶抑制剂B11抗体
合格 SERPINB12 丝氨酸蛋白酶抑制剂B12抗体
合格 CST8 胱抑素8/半胱氨酸蛋白酶抑制剂8抗体
合格 C1orf149 1号染色体开放阅读框149抗体
合格 C1orf187/Draxin 1号染色体开放阅读框187抗体
合格 C1orf183 1号染色体开放阅读框183抗体
合格 RNF14 环指蛋白14抗体
合格 合格 RNF156 环指蛋白156抗体
合格 RNF35 环指蛋白35抗体
合格 RNF24 环指蛋白24抗体
合格 RNF25 环指蛋白25抗体
合格 RNF21 环指蛋白21抗体
合格 RNF123 环指蛋白123抗体
合格 RNF128 环指蛋白128抗体
合格 RNF133 环指蛋白133抗体
合格 RNF138 环指蛋白138抗体
合格 RNF113B 环指蛋白113B抗体
合格 合格 RNF150 环指蛋白150抗体
合格 RNF169 环指蛋白169抗体
合格 RNF170 环指蛋白170抗体
合格 合格 RNF186 环指蛋白186抗体
合格 phospho-IRF3 (Ser386) 磷酸化干扰素调节因子3抗体