PRODH抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy- 5813R
英文名称PRODH
中文名称脯氨酸脱氢酶抗体
别 名HSPOX2; P53 induced gene 6 protein; PIG6; PRODH 1; PRODH 2; PRODH1; PRODH2; Proline dehydrogenase; proline dehydrogenase (oxidase) 1; proline dehydrogenase (proline oxidase); Proline oxidase, mitochondrial precursor; SCZD4; TP53I6; tumor protein p53 inducible protein 6; PROD_HUMAN.
说 明 书100ul 200ul
研究领域肿瘤 细胞生物 **学 信号转导 线粒体
抗体来源Rabbit
克隆类型Polyclonal
PRODH抗体交叉反应 Human, Mouse, Rat, Horse,
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
细胞定位细胞浆 线粒体
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PRODH
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
PRODH抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
Proline oxidase catalyzes the conversion of proline to pyrroline-5-carboxylate, or P5C during the degradation of the amino acid Proline. Defects in PRODH are the cause of hyperprolinemia type 1, a disorder characterized by elevated serum proline levels. Defective PRODH may be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome and may be associated with susceptibility to schizophrenia 4 (SCZD4).
Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
Subcellular Location:
Mitochondrion matrix.
Tissue Specificity:
Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
DISEASE:
Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Similarity:
Belongs to the proline oxidase family.
SWISS:
O43272
Gene ID:
5625
PRODH抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
PRODH抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 合格 Robo4 肿瘤血管内皮调节蛋白Robo4抗体
合格 BNIP3L 促凋亡BNIP3L蛋白抗体
合格 BAG3 Bcl2抑凋亡蛋白Bag3抗体
合格 BAG5 BCL2分子伴侣调节蛋白5抗体
合格 Lactoferrin 乳铁蛋白抗体
合格 PHLP 肿瘤抑制基因PHLPP抗体
合格 PRODH 脯氨酸脱氢酶抗体
合格 合格 RRAGA RAS相关GTP结合蛋白A抗体
合格 H Cadherin 心脏钙粘蛋白抗体
合格 K Cadherin 钙粘蛋白6抗体
合格 EMP3 上皮细胞膜蛋白3抗体
合格 ESAM 内皮细胞粘附分子抗体
合格 Galectin 8 半乳糖凝集素8抗体
合格 TAG1 瞬时表达轴索糖蛋白1抗体
合格 ADAM11 去整合素样金属蛋白酶11抗体
合格 合格 ADAM15 去整合素样金属蛋白酶15抗体
合格 ADAM18 去整合素样金属蛋白酶18抗体
合格 ADAM2 去整合素样金属蛋白酶2抗体
合格 ADAM23 去整合素样金属蛋白酶23抗体
合格 合格 ADAM28 去整合素样金属蛋白酶28抗体
合格 ADAMTS13 整合素样金属蛋白酶与凝血酶13型抗体
合格 合格 ADAMTSL4 整合素样金属蛋白酶与凝血酶样4蛋白抗体
合格 KLK6 激肽释放酶6抗体