Prostaglandin dehydrogenase 1抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy- 6051R
英文名称Prostaglandin dehydrogenase 1
中文名称前列腺素脱氢酶1抗体
别 名HPGD; Hydroxyprostaglandin dehydrogenase 15 (NAD); NAD+ dependent 15 hydroxyprostaglandin dehydrogenase; PGDH; PGDH_HUMAN; PGDH1; Prostaglandin dehydrogenase 1; SDR36C1; Short chain dehydrogenase/reductase family 36C,member 1; 15 hydroxyprostaglandin dehydrogenase [NAD+]; 15 PGDH; 15-hydroxyprostaglandin dehydrogenase [NAD+]; 15-PGDH; 15PGDH.
JournalPMIDIFApplicationInternational Journal of Clinical and Experimental Pathology (2015)262615781.8910IHC-P
说 明 书100ul 200ul
研究领域**学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
Prostaglandin dehydrogenase 1抗体交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Prostaglandin dehydrogenase 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Prostaglandin dehydrogenase 1抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Function:
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
Subunit:
Homodimer.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Detected in colon epithelium (at protein level).
DISEASE:
Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Note=The disease is caused by mutations affecting the gene represented in this entry.
Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. Note=The disease is caused by mutations affecting the gene represented in this entry.
Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SWISS:
P15428
Gene ID:
3248
Prostaglandin dehydrogenase 1抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
Prostaglandin dehydrogenase 1抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 phospho-MEK5(Ser129) 磷酸化丝裂原活化蛋白激酶激酶5抗体
合格 phospho-MEK5(Ser137) 磷酸化丝裂原活化蛋白激酶激酶5抗体
合格 合格 合格 Phospho-TAK1(Ser192) 磷酸化转化生长因子β活化激酶1
合格 合格 phospho-ILK-1(Thr173) 磷酸化整合素连接激酶1抗体
合格 合格 phospho-IRS1 (Thr176) 磷酸化胰岛素受体底物1抗体
合格 phospho-IGF1R (Tyr980) 磷酸化胰岛素样生长因子1受体抗体
合格 phospho-IGF1R (Tyr1280) 磷酸化胰岛素样生长因子1受体抗体
合格 phospho-IGF1R (Tyr1165 + Tyr1166) 磷酸化胰岛素样生长因子1受体抗体
合格 phospho-ICAM1 (Tyr512) 磷酸化细胞间粘附分子1抗体
合格 合格 phospho-c-Jun (Thr91) 磷酸化原癌基因c-Jun抗体
合格 phospho-Smad3 (Ser213) 磷酸化细胞信号转导分子SMAD3抗体
合格 phospho-c-Jun(Thr239) 磷酸化原癌基因c-Jun抗体
合格 phospho-c-Jun (Thr249) 磷酸化原癌基因c-Jun抗体
合格 合格 phospho-c-Jun(Tyr170) 磷酸化原癌基因c-Jun抗体
合格 Phospho-MDM2(Thr218) 磷酸化双微体2癌基因抗体
合格 phospho-Tau (Ser416) 磷酸化微管相关蛋白抗体
合格 phospho-MBP(Thr232) 磷酸化髓鞘碱性蛋白抗体
合格 phospho-MBP(Tyr203) 磷酸化髓鞘碱性蛋白抗体
合格 合格 合格 phospho-P38 MAPK (Thr180) 磷酸化p38MAPK抗体