PSME2抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy- 19576R
英文名称PSME2
中文名称蛋白酶激活复合物亚基2抗体
别 名11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; Cell migration inducing protein 22; MCP activator 31 kD subunit; PA28 beta; PA28B; PA28beta; Proteasome (prosome macropain) activator subunit 2 (PA28 beta); Proteasome (prosome macropain) activator subunit 2; Proteasome activator 28 beta; Proteasome activator 28 subunit beta; Proteasome activator complex subunit 2; Proteasome activator hPA28 subunit beta; Proteasome activator subunit 2; PSME 2; PSME2; PSME2_HUMAN; REG beta; REG-beta; REGbeta.
说 明 书100ul 200ul
研究领域细胞生物 泛素
抗体来源Rabbit
克隆类型Polyclonal
PSME2抗体交叉反应 Human, Mouse, Rat, Pig,
产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PSME2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
PSME2抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Subunit:
Heterodimer of PSME1 and PSME2, which forms a hexameric ring.
Similarity:
Belongs to the PA28 family.
Gene ID:
5721
PSME2抗体（antibody,
Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
PSME2抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 TPSB2 肥大细胞类胰蛋白酶β2
合格 合格 GSTP1 谷胱甘肽硫转移酶pi基因/Glutathione S Transferase pi抗体
合格 phospho-IRS1 (Ser307) 磷酸化胰岛素受体底物p-IRS-1/2抗体
合格 p53BP1 p53结合蛋白1抗体
合格 RUNX1 急性髓细胞白血病1蛋白抗体
合格 BLNK B**细胞连接蛋白抗体
合格 Aurora C 有丝分裂激酶B抗体
合格 合格 CRK Crk p38抗体
合格 EIF2AK4/GCN2 蛋白激酶GCN2蛋白抗体
合格 GRB10 生长因子受体结合蛋白10抗体
合格 AMPK alpha 2 腺苷单磷酸活化蛋白激酶α2抗体
合格 LIMK1 单丝氨酸蛋白激酶1抗体
合格 CD44v7 CD44V7抗体
合格 CD44v10 CD44V10抗体
合格 合格 CACNA1G 电压依赖性钙通道Cav3.1抗体
合格 CD44v5 CD44V5抗体
合格 CD44v4 CD44V4抗体
合格 Tap1 ATP结合转运因子1抗体
合格 Claudin 4 紧密连接蛋白4抗体
合格 CRHR1 促肾上腺皮质释放**受体1抗体
合格 合格 CRHR2 促肾上腺皮质释放**受体2抗体
合格 MYL1+3 肌球蛋白轻链1/3抗体
合格 NAT2 N-乙酰基转移酶2抗体
合格 合格 Endo G 核酸内切酶G抗体
合格 Cardiac Troponin T 心肌特异性肌钙蛋白T抗体
合格 CD161/NK1.1 CD161抗体