Rarres3抗体特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而，抗体可通过与病毒或**的特异性结合，直接发挥中和病毒的作用。
产品编号xy-1917R 英文名称Rarres3 中文名称视黄酸受体应答蛋白3抗体 别 名Retinoic acid receptor responder protein 3; HRASLS4; MGC8906; RAR responsive protein TIG3; Retinic acid inducible gene 1; Retinoic acid receptor responder (tazarotene induced) 3; Retinoid inducible gene 1 protein; RIG 1; rig1; Tazarotene induced gene 3 protein; TIG 3; TIG3; p18H-rev 107; Group XVI phospholipase A2; HRAS-like; rCG47447; HRSL4_HUMAN; HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoid-inducible gene 1 protein. 说 明 书100ul 200ul 研究领域心血管 **学 神经生物学 抗体来源Rabbit 克隆类型Polyclonal Rarres3抗体交叉反应 Human, Dog, Rabbit, 产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量18kDa 细胞定位细胞膜 性 状Lyophilized or Liquid 浓 度1mg/1ml 免 疫 原KLH conjugated synthetic peptide derived from human Rarres3 亚 型IgG 纯化方法affinity purified by Protein A 储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMedPubMed Rarres3抗体产品介绍background: Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]. Function: Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. Subcellular Location: Membrane; Single-pass membrane protein. Tissue Specificity: Widely expressed. Similarity: Belongs to the H-rev107 family. SWISS: Q9UL19 Gene ID: 5920
英文名称Rarres3
中文名称视黄酸受体应答蛋白3抗体
别 名Retinoic acid receptor responder protein 3; HRASLS4; MGC8906; RAR responsive protein TIG3; Retinic acid inducible gene 1; Retinoic acid receptor responder (tazarotene induced) 3; Retinoid inducible gene 1 protein; RIG 1; rig1; Tazarotene induced gene 3 protein; TIG 3; TIG3; p18H-rev 107; Group XVI phospholipase A2; HRAS-like; rCG47447; HRSL4_HUMAN; HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoid-inducible gene 1 protein.
说 明 书100ul 200ul
研究领域心血管 **学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
Rarres3抗体交叉反应 Human, Dog, Rabbit,
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Rarres3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
Rarres3抗体产品介绍background:
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008].
Function:
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.
Subcellular Location:
Membrane; Single-pass membrane protein.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the H-rev107 family.
SWISS:
Q9UL19
Gene ID:
5920
Rarres3抗体（antibody, Ab）是由效应B细胞（效应**B细胞）分泌，机体用于抵御外来物质，如病毒，**等抗原，结构呈“Y”字型的球状蛋白质，仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质，均被称作抗原，因此对于抗抗体（能够结合抗体的抗体）来说，抗体本身也是一种抗原物质。
Rarres3抗体普通抗体重链和轻链的结构
重链结构：普通的**球蛋白具有2条重链（H链），分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型，对应的**球蛋白名称分别为IgM、IgG、IgA、IgD和IgE。
轻链结构： 普通**球蛋白具有2条轻链（L链），分子质量约25kDa，有κ链和λ链两种亚型，这两种轻链决定了Ig的亚型类别（IgG1，IgG2，IgG3，IgG4）。一个天然的Ig分子两条轻链总是相同的，但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同，正常人血清**球蛋白κ链：λ链约为2：1，而在小鼠的比例为20：1。
2.2抗体Fab段和Fc段
IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1个Fc段,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应；经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab’)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段（fragment of antigen binding，Fab），相当于抗体分子的两个臂，由一个完整的轻链和重链的VH和CH1结构域组成。Fc段为可结晶段（fragment crystallizable，Fc）相当于Ig的CH2和CH3结构域，是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区，以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2和CH3的区域，相当于Y字结构下面那一部分。
合格 HMG2L1 高迁移率族蛋白2样蛋白1抗体 合格 HMGN3 高迁移率族蛋白N3抗体 合格 HMX1 HMX1蛋白抗体 合格 PELP1 HMX3蛋白抗体 合格 HNF6 肝细胞核因子6抗体 合格 phospho-TGF beta Receptor II (Tyr259) 磷酸化转移生长因子β受体2抗体 合格 合格 HLA A2 组织相容性复合物A2抗体 合格 phospho-Hsp90 beta (Ser226) 磷酸化热休克蛋白90β抗体 合格 HSPA12A 热休克蛋白70蛋白12A抗体 合格 合格 合格 GPR78 G蛋白偶联受体78抗体 合格 HSPA2 热休克蛋白70蛋白2抗体 合格 HSPC111 HSPC111蛋白抗体 合格 合格 Haptoglobin 结合珠蛋白/触珠蛋白抗体 合格 合格 HTRA4 丝氨酸肽酶4抗体 合格 hUPF2/RENT2 hUPF2蛋白抗体 合格 HUS1B 检查点蛋白HUS1B抗体 合格 LDHA 乳酸脱氢酶抗体 合格 HYAL4 透明质酸酶4抗体 合格 C12orf72 12号染色体开放阅读框72抗体 合格 IFNA17 干扰素α17抗体 合格 phospho-IKB alpha (Ser32) 磷酸化核因子κB抑制蛋白α抗体 合格 合格 phospho-IKB alpha (Ser36) 磷酸化核因子κB抑制蛋白α抗体体 合格 IGLC1 **球蛋白λ轻链恒定区1抗体 合格 合格 IL3 beta 白细胞介素3β抗体