RIP2抗体

RIP2抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-3546R

英文名称RIP2

中文名称受体结合丝氨酸苏氨酸激酶2抗体

别    名Receptor interacting protein 2; Receptor interacting serine threonine kinase 2; Receptor interacting serine/threonine protein kinase 2; RICK; RIP 2; RIP LIKE INTERACTING CLARP KINASE; RIPK 2; RIPK2; TNFRSF; CARD 3; CARD carrying kinase; CARD CONTAINING ICE ASSOCIATED KINASE; CARD containing IL 1 beta ICE kinase; CARD containing IL1 beta ICE kinase; CARD containing interleukin 1 beta converting enzyme (ICE) associated kinase; CARD containing interleukin 1 beta converting enzyme associated kinase; CARD3; CARDIAK; CCK; CLARP kinase; GIG 30; GIG30 ; Growth inhibiting gene 30; Receptor interacting protein (RIP) like interacting caspase like apoptosis regulatory protein (CLARP) kinase.  

说 明 书100ul  200ul

研究领域肿瘤  细胞生物  **学  细胞膜受体  

抗体来源Rabbit

克隆类型Polyclonal

RIP2抗体交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量60kDa

细胞定位细胞浆

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human RIP2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

RIP2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.

Function:

Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.

Subunit:

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 1 CARD domain. Contains 1 protein kinase domain.

Subcellular Location:

Cytoplasm.

Tissue Specificity:

Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.

Post-translational modifications:

Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH.

Similarity:

Belongs to the protein kinase superfamily.

TKL Ser/Thr protein kinase family.

Contains 1 CARD domain.

Contains 1 protein kinase domain.

SWISS:

O43353

Gene ID:

8767