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phospho-STAT5b (Ser731)抗体

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产品名称: phospho-STAT5b (Ser731)抗体
产品型号:
产品展商: XYbscience
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简单介绍

phospho-STAT5b (Ser731)抗体实现双重功能:信号转导和转录激活。phospho-STAT5b (Ser731)抗体与气体元素结合并激活PRL诱导的转录。


phospho-STAT5b (Ser731)抗体  的详细介绍

phospho-STAT5b (Ser731)抗体特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而,抗体可通过与病毒或**的特异性结合,直接发挥中和病毒的作用。

产品编号xy- 5703R

英文名称phospho-STAT5b (Ser731)

中文名称磷酸化信号转导和转录激活因子5b抗体

别    名STAT5b (phospho S731); p-STAT5b (phospho S731); STAT5b(phospho S731); Transcription factor STAT5B; Signal transducer and activator of transcription 5B; STA5B_HUMAN; STAT5; Stat5b.  

说 明 书100ul  

产品类型磷酸化抗体

研究领域肿瘤  细胞生物  **学  染色质和核信号  信号转导  转录调节因子  

抗体来源Rabbit

克隆类型Polyclonal

phospho-STAT5b (Ser731)抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 (石蜡切片需做抗原修复)

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量90kDa

细胞定位细胞核 细胞浆

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated Synthesised phosphopeptide derived from human STAT5b around the phosphorylation site of Ser731:AP(p-S)PA

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

phospho-STAT5b (Ser731)抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.


Function:

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.


Subunit:

Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7. Interacts (via SH2 domain) with INSR.


Subcellular Location:

Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).


Post-translational modifications:

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.


DISEASE:

Growth hormone insensitivity with immunodeficiency (GHII) [MIM:245590]: A disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections. Note=The disease is caused by mutations affecting the gene represented in this entry.


Similarity:

Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.


SWISS:

P51692


Gene ID:

6777

phospho-STAT5b (Ser731)抗体antibody, Ab)是由效应B细胞(效应**B细胞)分泌,机体用于抵御外来物质,如病毒,**等抗原,结构呈“Y”字型的球状蛋白质,仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质,均被称作抗原,因此对于抗抗体(能够结合抗体的抗体)来说,抗体本身也是一种抗原物质。

   QQ图片20171030091318

phospho-STAT5b (Ser731)抗体普通抗体重链和轻链的结构

重链结构:普通的**球蛋白具有2条重链(H链),分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型,对应的**球蛋白名称分别为IgMIgGIgAIgDIgE

轻链结构:  普通**球蛋白具有2条轻链(L链),分子质量约25kDa,有κ链和λ链两种亚型,这两种轻链决定了Ig的亚型类别(IgG1IgG2IgG3IgG4)。一个天然的Ig分子两条轻链总是相同的,但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同,正常人血清**球蛋白κ链:λ链约为21,而在小鼠的比例为201

2.2抗体Fab段和Fc

IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1Fc,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应;经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段(fragment of antigen bindingFab),相当于抗体分子的两个臂,由一个完整的轻链和重链的VHCH1结构域组成。Fc段为可结晶段(fragment crystallizableFc)相当于IgCH2CH3结构域,是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区,以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2CH3的区域,相当于Y字结构下面那一部分。

合格 ERO1LB Ero1-Lβ蛋白抗体
合格 合格 ERp57 内质网蛋白57抗体
合格 ETS2.3 ETS2.3蛋白抗体
合格 Phospho-Estrogen Receptor alpha (Ser104) 磷酸化雌**受体α抗体
合格 合格 Phospho-Estrogen Receptor alpha (Ser106) 磷酸化雌**受体α抗体
合格 EVI5L EVI5L蛋白抗体
合格 EVPLL EVPLL蛋白抗体
合格 EVX2 EVX2蛋白抗体
合格 合格 EXD2 EXD2蛋白抗体
合格 EXD3 EXD3蛋白抗体
合格 EXOC1 EXOC1蛋白抗体
合格 GRB2 生长因子受体结合蛋白2抗体
合格 EXOC3L2 EXOC3L2蛋白/Hepatitis B Virus X antigen抗体
合格 合格 EXOC6B EXOC6B蛋白抗体
合格 EXOC8 EXOC8蛋白抗体
合格 EXOSC4 EXOSC4蛋白抗体
合格 EXOSC5 EXOSC5蛋白抗体
合格 EXT1 多发性外生骨疣蛋白1抗体
合格 FBXO3 F-box蛋白家族FBXO3抗体
合格 FA83D FA83D蛋白抗体
合格 FAAP24 FAAP24蛋白抗体
合格 MDR1/P Glycoprotein 多药耐药蛋白/P-糖蛋白抗体(C端)
合格 FAM108A1 FAM108A1蛋白抗体
合格 FAM114A2 FAM114A2蛋白抗体
 


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