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Proteasome 26S S2抗体

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产品名称: Proteasome 26S S2抗体
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产品展商: XYbscience
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简单介绍

Proteasome 26S S2抗体是一种multicatalytic蛋白酶复合体具有高度有序的结构由2个配合物,一个20多岁的核心和19S调节复合体。28个不同的亚基由4个环组成,2个环由7个α亚基组成,2个环由7个β亚基组成。19S调节是由底座,其中包含6个ATP酶亚基和2个非ATP酶亚基和一个盖子,里面包含了10个非ATP酶亚基。蛋白酶体是分布在真核细胞在高浓度和裂解肽在ATP /泛素依赖的过程中的非溶酶体途径。一种改进的蛋白酶,蛋白酶的重要功能,是I类MHC肽的处理。该基因编码一个盖子的19S调节非ATP酶亚基。Proteasome 26S S2抗体除了参与蛋白酶体功能外,此亚基也参与TNF信号通路,因为它与肿瘤坏死因子1受体相互作用。一个假基因已确定1号染色体。选择性剪接导致该基因的多个转录变异体。


Proteasome 26S S2抗体  的详细介绍

Proteasome 26S S2抗体特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而,抗体可通过与病毒或**的特异性结合,直接发挥中和病毒的作用。

产品编号xy- 9363R

英文名称Proteasome 26S S2

中文名称肿瘤坏死因子受体相关蛋白2抗体

别    名26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; MGC14274; P97 antibody Proteasome (prosome macropain) 26S subunit non ATPase 2; Protein 55.11; Psmd2; PSMD2_HUMAN; Rpn1; S2 antibody TNFR associated protein 2; TRAP2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2.  

说 明 书100ul  200ul

研究领域肿瘤  细胞生物  细胞周期蛋白  细胞分化  

抗体来源Rabbit

克隆类型Polyclonal

Proteasome 26S S2抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复)

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量100kDa

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human Proteasome 26S S2/TRAP2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Proteasome 26S S2抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]


Function:

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.


Tissue Specificity:

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.


Similarity:

Belongs to the proteasome subunit S2 family.

Contains 7 PC repeats.


Gene ID:

5708

Proteasome 26S S2抗体antibody, Ab)是由效应B细胞(效应**B细胞)分泌,机体用于抵御外来物质,如病毒,**等抗原,结构呈“Y”字型的球状蛋白质,仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质,均被称作抗原,因此对于抗抗体(能够结合抗体的抗体)来说,抗体本身也是一种抗原物质。

   QQ图片20171030091318

Proteasome 26S S2抗体普通抗体重链和轻链的结构

重链结构:普通的**球蛋白具有2条重链(H链),分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型,对应的**球蛋白名称分别为IgMIgGIgAIgDIgE

轻链结构:  普通**球蛋白具有2条轻链(L链),分子质量约25kDa,有κ链和λ链两种亚型,这两种轻链决定了Ig的亚型类别(IgG1IgG2IgG3IgG4)。一个天然的Ig分子两条轻链总是相同的,但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同,正常人血清**球蛋白κ链:λ链约为21,而在小鼠的比例为201

2.2抗体Fab段和Fc

IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1Fc,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应;经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段(fragment of antigen bindingFab),相当于抗体分子的两个臂,由一个完整的轻链和重链的VHCH1结构域组成。Fc段为可结晶段(fragment crystallizableFc)相当于IgCH2CH3结构域,是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区,以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2CH3的区域,相当于Y字结构下面那一部分。

合格 合格 phospho-ATF2 (Ser322) 磷酸化活化复制因子2抗体
合格 合格 phospho-ATF2 (Ser62 / Ser44) 磷酸化活化复制因子2抗体
合格 phospho-ATF2 (Ser94) 磷酸化活化复制因子2抗体
合格 phospho-ATF2 (Thr51) 磷酸化活化复制因子2抗体
合格 phospho-APC1 (Ser377) 磷酸化细胞周期末期促进复合蛋白APC1抗体
合格 phospho-DDIT3 (Ser30) 磷酸化GADD153抗体
合格 phospho-AXL (Tyr698+Tyr702+Tyr703) 磷酸化粘附相关激酶抗体
合格 合格 合格 phospho-AKT1 + AKT2 + AKT3 (Thr308+Thr309+Thr305) 磷酸化蛋白激酶B抗体
合格 phospho-AQP2 (Ser264) 磷酸化水通道蛋白2抗体
合格 phospho-Androgen Receptor (Ser213) 磷酸化雄**受体抗体
合格 合格 合格 phospho-AKT1+AKT2+AKT3 (Tyr315+316+312) 磷酸化蛋白激酶AKT1,2,3抗体
合格 合格 合格 phospho-AKT1(Thr34) 磷酸化蛋白激酶B抗体
合格 phospho-ATG4D (Ser467) 磷酸化自噬相关蛋白4D抗体
合格 phospho-ATG3 (Tyr18) 磷酸化自噬相关蛋白3抗体
合格 phospho-AKT3 (Ser472) 磷酸化蛋白激酶AKT3抗体
合格 Phospho-Bad (Ser118) 磷酸化相关死亡促进因子抗体
合格 合格 合格 Phospho-Bcl-2 (Thr129) 磷酸化Bcl-2抗体
合格 Cardiodilatin-related peptide 心舒血管素相关肽抗体
合格 合格 合格 phospho-CDKN1B (Thr157) 磷酸化P27抗体/周期素依赖激酶抑制剂抗体
合格 phospho-CDKN1B (Thr187) 磷酸化P27抗体/周期素依赖激酶抑制剂抗体
合格 phospho-Bid (Ser61) 磷酸化BH3结构域凋亡诱导蛋白抗体
 


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