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PSMD11抗体

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产品名称: PSMD11抗体
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产品展商: XYbscience
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简单介绍

PSMD11抗体26S蛋白酶体是一种multicatalytic蛋白酶复合体具有高度有序的结构由2个配合物,一个20多岁的核心和19S调节复合体。28个不同的亚基由4个环组成,2个环由7个α亚基组成,2个环由7个β亚基组成。19S调节是由底座,其中包含6个ATP酶亚基和2个非ATP酶亚基和一个盖子,里面包含了10个非ATP酶亚基。PSMD11抗体蛋白酶体是分布在真核细胞在高浓度和裂解肽在ATP /泛素依赖的过程中的非溶酶体途径。该基因编码的蛋白酶体亚单位的一员,作为S9系列的19S调节非ATP酶亚基和磷酸化腺苷酸活化蛋白激酶。选择性剪接变异体已被观察到。[由RefSeq提供,月2012日]


PSMD11抗体  的详细介绍

PSMD11抗体特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而,抗体可通过与病毒或**的特异性结合,直接发挥中和病毒的作用。

产品编号xy- 19466R

英文名称PSMD11

中文名称26S蛋白酶体非ATP酶调节亚基11抗体

别    名26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; MGC3844; p44.5; protease 26S, subunit, 9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; proteasome 26S subunit, non-ATPase, 11; PSD11_HUMAN; PSMD 11; PSMD11; Rpn6; S9.  

说 明 书100ul  200ul

研究领域细胞生物  泛素  

抗体来源Rabbit

克隆类型Polyclonal

PSMD11抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish, Guinea Pig, Cat,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量38kDa

细胞定位细胞核 细胞浆

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human PSMD11

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

PSMD11抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]


Function:

Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.


Subcellular Location:

Nucleus. Cytoplasm > cytosol.


Tissue Specificity:

Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.


Post-translational modifications:

Phosphorylated by AMPK.


Similarity:

Belongs to the proteasome subunit S9 family.

Contains 1 PCI domain.


SWISS:

O00231


Gene ID:

5717


PSMD11抗体antibody, Ab)是由效应B细胞(效应**B细胞)分泌,机体用于抵御外来物质,如病毒,**等抗原,结构呈“Y”字型的球状蛋白质,仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质,均被称作抗原,因此对于抗抗体(能够结合抗体的抗体)来说,抗体本身也是一种抗原物质。

   QQ图片20171030091318

PSMD11抗体普通抗体重链和轻链的结构

重链结构:普通的**球蛋白具有2条重链(H链),分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型,对应的**球蛋白名称分别为IgMIgGIgAIgDIgE

轻链结构:  普通**球蛋白具有2条轻链(L链),分子质量约25kDa,有κ链和λ链两种亚型,这两种轻链决定了Ig的亚型类别(IgG1IgG2IgG3IgG4)。一个天然的Ig分子两条轻链总是相同的,但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同,正常人血清**球蛋白κ链:λ链约为21,而在小鼠的比例为201

2.2抗体Fab段和Fc

IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1Fc,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应;经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段(fragment of antigen bindingFab),相当于抗体分子的两个臂,由一个完整的轻链和重链的VHCH1结构域组成。Fc段为可结晶段(fragment crystallizableFc)相当于IgCH2CH3结构域,是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区,以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2CH3的区域,相当于Y字结构下面那一部分。

合格 Phospho-FoxO1 (Ser319) 磷酸化叉头蛋白家族1抗体
合格 Phospho-FoxO1 (Ser256) 磷酸化叉头蛋白家族1抗体
合格 合格 phospho-FOXO4 (Ser262) 磷酸化叉头蛋白4抗体
合格 phospho-GSK-3 Beta(Thr390) 磷酸化糖原合酶激酶3β抗体
合格 合格 Phospho-c-Fos (Ser32) 磷酸化c-fos抗体
合格 Phospho-c-Fos(Thr232) 磷酸化c-fos抗体
合格 合格 Phospho-c-Fos (Thr325) 磷酸化c-fos抗体
合格 Phospho-GCN2 (Thr899) 磷酸化蛋白激酶GCN2蛋白抗体
合格 合格 合格 Phospho-FAK (Tyr397) 磷酸化粘着斑激酶抗体
合格 合格 Phospho-FAK(Tyr861) 磷酸化粘着斑激酶抗体
合格 Phospho-GSK3 alpha (Ser21) 磷酸化糖原合酶激酶3α抗体
合格 Phospho-FAK(Tyr576 + Tyr577) 磷酸化粘着斑激酶抗体
合格 合格 Phospho-FAK (Tyr407) 磷酸化粘着斑激酶抗体
合格 合格 phospho-c-Jun (Ser73) 磷酸化原癌基因c-Jun抗体
合格 合格 phospho-c-Jun (Ser243) 磷酸化原癌基因c-Jun抗体
合格 Phospho-HDAC3 (Ser424) 磷酸化组蛋白去乙酰化酶3抗体
合格 phospho-Histone H1.4 (Thr146) 磷酸化组蛋白H1抗体
合格 phospho-GAB2 (Ser159) 磷酸化接头蛋白Gab2抗体
合格 phospho-GAB2 (Tyr452) 磷酸化接头蛋白Gab 2抗体
合格 合格 Phospho-HSP27(Ser78) 磷酸化热休克蛋白27抗体
合格 Phospho-HSP27 (Ser82) 磷酸化热休克蛋白27抗体
合格 Phospho-Histone H3 (Ser10) 磷酸化组蛋白H3抗体
合格 Phospho-Histone H3 (Ser28) 磷酸化组蛋白H3抗体
 


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