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RAB23抗体

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产品名称: RAB23抗体
产品型号:
产品展商: XYbscience
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简单介绍

RAB23抗体RAS相关家族的鸟嘌呤核苷酸结合蛋白包括R-Ras,说唱,RAL / REC和Rho/RAB亚科。越来越多的数据表明,在细胞内吞作用或生物合成的蛋白质转运的Rab蛋白的重要作用。新合成的蛋白质从内质网运输到高尔基体堆叠的各种过程和涉及的载体囊泡分泌囊泡的运动和需要Rab蛋白的功能。Rab蛋白也是细胞内吞途径的一个组成部分。Rab 23,也被称为hspc137,是一个237个氨基酸的蛋白质的Rab家族的成员,定位于细胞膜的胞质面。23是认为RAB蛋白在细胞内的运输和小G蛋白介导的信号转导中起着重要的作用。RAB23抗体在木匠征RAB 5月23日结果的突变基因编码,也被称为acps2(尖头并指多指2型),一个条件主要表现为肥胖、心脏畸形、多指、颅缝早闭。


RAB23抗体  的详细介绍

RAB23抗体特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而,抗体可通过与病毒或**的特异性结合,直接发挥中和病毒的作用。

产品编号xy- 12389R

英文名称RAB23

中文名称G蛋白偶联受体RAB23抗体

别    名DKFZp781H0695; HSPC137; MGC8900; Rab 23; RAB family small GTP binding protein RAB 23; Rab23; RAB23, member RAS oncogene family; RAB23_HUMAN; Ras related protein Rab 23; Ras-related protein Rab-23.  

说 明 书100ul  200ul

研究领域肿瘤  染色质和核信号  神经生物学  干细胞  G蛋白偶联受体  G蛋白信号  

抗体来源Rabbit

克隆类型Polyclonal

RAB23抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量23kDa

细胞定位细胞浆 细胞膜

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human RAB23

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

RAB23抗体保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.


Function:

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.


Subunit:

Interacts with SUFU.


Subcellular Location:

Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cell membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane (By similarity). Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.


DISEASE:

Defects in RAB23 are the cause of acrocephalopolysyndactyly type 2 (ACPS2) [MIM:201000]. A syndrome characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects.


Similarity:

Belongs to the small GTPase superfamily. Rab family.


SWISS:

Q9ULC3


Gene ID:

51715

RAB23抗体antibody, Ab)是由效应B细胞(效应**B细胞)分泌,机体用于抵御外来物质,如病毒,**等抗原,结构呈“Y”字型的球状蛋白质,仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质,均被称作抗原,因此对于抗抗体(能够结合抗体的抗体)来说,抗体本身也是一种抗原物质。

   QQ图片20171030091318

RAB23抗体普通抗体重链和轻链的结构

重链结构:普通的**球蛋白具有2条重链(H链),分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型,对应的**球蛋白名称分别为IgMIgGIgAIgDIgE

轻链结构:  普通**球蛋白具有2条轻链(L链),分子质量约25kDa,有κ链和λ链两种亚型,这两种轻链决定了Ig的亚型类别(IgG1IgG2IgG3IgG4)。一个天然的Ig分子两条轻链总是相同的,但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同,正常人血清**球蛋白κ链:λ链约为21,而在小鼠的比例为201

2.2抗体Fab段和Fc

IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1Fc,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应;经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段(fragment of antigen bindingFab),相当于抗体分子的两个臂,由一个完整的轻链和重链的VHCH1结构域组成。Fc段为可结晶段(fragment crystallizableFc)相当于IgCH2CH3结构域,是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区,以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2CH3的区域,相当于Y字结构下面那一部分。

合格 PRPF4 PRPF4蛋白抗体
合格 EGF 表皮生长因子抗体
合格 Angiotensin III 血管紧张素III抗体
合格 ADAM9 去整合素样金属蛋白酶9抗体
合格 EGF 表皮生长因子抗体
合格 RanBP3 RAN结合蛋白3抗体
合格 HDLBP 高密度脂蛋白结合蛋白抗体
合格 Collagen alpha-1(I) chain I型胶原蛋白
合格 MDH2 线粒体苹果酸脱氢酶2抗体
合格 SCN1A SCN1A抗体
合格 NIT2 NIT2蛋白抗体
合格 FAIM3 FAS凋亡抑制分子3抗体
合格 DLC1 肝癌缺失基因1抗体
合格 DLC2 肝癌缺失基因2抗体
合格 GSK3 alpha 糖原合酶激酶3α抗体
合格 BPNT1 二磷酸3核苷酸酶抗体
合格 phospho-Nrf2 (Ser40) 磷酸化核因子2相关因子2(Ser40)抗体
合格 SFRS9 丝氨酸/苏氨酸SFRS9抗体
合格 ZNF703 锌指蛋白703抗体
合格 FAM166A FAM166A蛋白抗体
合格 DNCLI1 胞质动力蛋白轻链中间体1抗体
合格 MVK 甲羟戊酸激酶抗体
合格 合格 PCDH7 原钙粘蛋白7抗体
合格 MVK 甲羟戊酸激酶抗体
 


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