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RANK抗体

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产品名称: RANK抗体
产品型号:
产品展商: XYbscience
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简单介绍

RANK抗体是肿瘤坏死因子受体(TNFR)家族的一员。人类和小鼠的cd265分享81%的氨基酸同一性在它们的胞外结构域。cd265广泛表达,在骨骼肌、肝脏、胸腺水平*高、结肠、小肠、肾上腺。cd265也在树突状细胞中表达。秩和位配体(RANKL)是T细胞与树突状细胞相互作用的重要调节因子。RANK受体对破骨细胞的破骨细胞分化因子。多个肿瘤坏死因子受体相关因子(因子)参与cd265信令。RANK抗体恍惚(肿瘤坏死因子相关激活诱导的细胞因子,也被称为配体,骨保护素配体和破骨细胞分化因子)是cd265配体。生物功能介导的等级包括NF-κB和cJun氨基末端激酶活化T细胞生长和树突状细胞功能增强,破骨细胞和**器官的诱导。对cd265可溶性形式能够阻止恍惚诱导的生物活性。对anti-cd265细胞表面cd265结合触发信号转导和诱导cd265介导的生物活性。


RANK抗体  的详细介绍

RANK抗体特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而,抗体可通过与病毒或**的特异性结合,直接发挥中和病毒的作用。

产品编号xy-2695R

英文名称RANK

中文名称核转录因子NF-κB受体抗体(核因子kB受体活化因子)

别    名TNFRSF11A; CD265; CD265 antigen; Activator of NFKB; EOF; FEO; mRANK; NFKB activator; ODFR; OFE; Osteoclast differentiation factor receptor; PDB 2; Receptor activator of NF KB; receptor activator of nuclear factor kappa B; TNFRSF 11A; TNFSF11; TRANCE R; RANK receptor; TNR11_HUMAN.  

说 明 书50ul  100ul  200ul

研究领域肿瘤  细胞生物  转录调节因子  细胞表面分子  

抗体来源Rabbit

克隆类型Polyclonal

RANK抗体交叉反应 Human, Mouse, Rat,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg /test IF=1:100-500 (石蜡切片需做抗原修复)

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量63-70kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human RANK C-terminus

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

RANK抗体产品介绍background:

CD265 is a member of the tumor necrosis factor receptor (TNFR) family. Human and murine CD265 share 81% amino acid identity in their extracellular domains. CD265 is widely expressed, with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. CD265 is also expressed in dendritic cells. RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of CD265. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for CD265. The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis. The soluble form of CD265 is able to block TRANCE induced biological activity. The binding of anti-CD265 to cell surface CD265 triggers signal transduction and induces CD265 mediated bioactivity.


Function:

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.


Subcellular Location:

Membrane.


Tissue Specificity:

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.


DISEASE:

Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO) [MIM:174810]. FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early *****hood. FEO is often associated with early onset deafness and loss of dentition.

Defects in TNFRSF11A are a cause of Paget disease of bone type 2 (PDB2) [MIM:602080]; also known as familial Paget disease of bone. PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Unlike FEO, however, affected individuals have involvement of the axial skeleton with lesions in the spine, pelvis and skull.


Similarity:

Contains 4 TNFR-Cys repeats.


SWISS:

Q9Y6Q6


Gene ID:

8792


RANK抗体antibody, Ab)是由效应B细胞(效应**B细胞)分泌,机体用于抵御外来物质,如病毒,**等抗原,结构呈“Y”字型的球状蛋白质,仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质,均被称作抗原,因此对于抗抗体(能够结合抗体的抗体)来说,抗体本身也是一种抗原物质。

   QQ图片20171030091318

RANK抗体普通抗体重链和轻链的结构

重链结构:普通的**球蛋白具有2条重链(H链),分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型,对应的**球蛋白名称分别为IgMIgGIgAIgDIgE

轻链结构:  普通**球蛋白具有2条轻链(L链),分子质量约25kDa,有κ链和λ链两种亚型,这两种轻链决定了Ig的亚型类别(IgG1IgG2IgG3IgG4)。一个天然的Ig分子两条轻链总是相同的,但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同,正常人血清**球蛋白κ链:λ链约为21,而在小鼠的比例为201

2.2抗体Fab段和Fc

IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1Fc,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应;经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段(fragment of antigen bindingFab),相当于抗体分子的两个臂,由一个完整的轻链和重链的VHCH1结构域组成。Fc段为可结晶段(fragment crystallizableFc)相当于IgCH2CH3结构域,是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区,以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2CH3的区域,相当于Y字结构下面那一部分。

合格 PPARGC1A 过氧化物酶体增殖物激活受体γ辅激活子1α抗体
合格 RNF127/LONRF3 环指蛋白127抗体
合格 Vesicular Acetylcholine Transporter 囊泡乙酰胆碱通道抗体
合格 LPCAT1 溶血卵磷脂酰基转移酶1抗体
合格 LPLUNC3 鼻咽癌相关蛋白抗体
合格 LRBA LRBA蛋白抗体
合格 LRP11 低密度脂蛋白受体相关蛋白11抗体
合格 LRRC14 富含亮氨酸重复蛋白14抗体
合格 LRRC17 富含亮氨酸重复蛋白17抗体
合格 LRRC20 富含亮氨酸重复蛋白20抗体
合格 LRRC33 富含亮氨酸重复蛋白33抗体
合格 LRRC34 富含亮氨酸重复蛋白34抗体
合格 LRTM2 富含亮氨酸重复序列跨膜结构域2抗体
合格 LSM11 LSM11蛋白抗体
合格 LSMD1 LSMD1蛋白抗体
合格 LEF-1 **增强因子-1抗体
合格 LTV1/C6orf93 6号染色体开放阅读框93抗体
合格 LUZP2 亮氨酸拉链蛋白2抗体
合格 LW1/HSFX1 热休克转录因子家族X连锁1抗体
合格 LXR beta 肝脏X受体β抗体
合格 LXR alpha + LXR beta 肝脏X受体α+肝脏X受体β抗体
合格 LY6G5C/C6orf20 6号染色体开放阅读框20抗体
合格 合格 ZBTB9/ZNF919 锌指蛋白ZNF919抗体
合格 ZC3H11A ZC3H11A蛋白抗体
 

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