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RBCK1/HBV associated factor 4抗体

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产品名称: RBCK1/HBV associated factor 4抗体
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产品展商: XYbscience
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简单介绍

RBCK1/HBV associated factor 4抗体该基因编码的蛋白质类似于鼠标Ubcm4 uip28 /相互作用蛋白。RBCK1/HBV associated factor 4抗体在这个位点已经观察到选择性剪接,从而导致不同的亚型。[由RefSeq提供,月2008日]


RBCK1/HBV associated factor 4抗体  的详细介绍

RBCK1/HBV associated factor 4抗体特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以**病原微生物或导致病理损伤。然而,抗体可通过与病毒或**的特异性结合,直接发挥中和病毒的作用。

产品编号xy- 19761R

英文名称RBCK1/HBV associated factor 4

中文名称乙型肝炎X病毒相关蛋白4抗体

别    名XAP3; XAP4; HOIL1; PBMEI; PGBM1; RBCK2; RNF54; HOIL-1; ZRANB4; C20orf18; UBCE7IP3; Chromosome 20 open reading frame 18; HBV associated factor 4; HBV-associated factor 4; Heme-oxidized IRP2 ubiquitin ligase 1; Hepatitis B virus X associated protein 4; Hepatitis B virus X-associated protein 4; HOIL 1L; HOIL-1L; HOIL1; HOIL1L; RanBP type and C3HC4 type zinc finger containing 1; RanBP-type and C3HC4-type zinc finger-containing protein 1; RBCC protein interacting with PKC1; Rbck1; RBCK2; RING finger protein 54; RNF54; UB7I3_HUMAN; UBCE7IP3; Ubiquitin conjugating enzyme 7 interacting protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 3.  

说 明 书100ul  200ul

研究领域转录调节因子  **及病毒  锌指蛋白  表观遗传学  泛素  

抗体来源Rabbit

克隆类型Polyclonal

RBCK1/HBV associated factor 4抗体交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量56kDa

细胞定位细胞核

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human RBCK1/HBV associated factor 4

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

RBCK1/HBV associated factor 4抗体产品介绍background:

The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]


Function:

Acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteoasome. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. LUBAC conjugates linear polyubiquitin to IKBKG at 'Lys-285' and 'Lys-309' and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.


Subcellular Location:

Forms homodimers in vitro (By similarity). Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Interacts with beta-I-type (PRKCB1) and zeta-type protein kinase C (PRKCZ) and with UBE2L3. Interacts with PRKCH. Interacts with the HBV pX/HBx protein, which is required to activate transcription of the viral genome. Isoform 1 and isoform 2 interact with IREB2 only in iron-rich conditions. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner. Interacts with EYA1, TAB2, TAB3, MAP3K7 TRAF6 and RIPK1. Interacts with IRF3.


Post-translational modifications:

Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome. Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity.


DISEASE:

The disease is caused by mutations affecting the gene represented in this entry.

Disease description:A disease characterized by polyglucosan storage myopathy associated with early-onset progressive muscle weakness and progressive dilated cardiomyopathy, which may necessitate cardiac transplant in severe cases. Some patients present with severe immunodeficiency, invasive bacterial infections and chronic autoinflammation.


Similarity:

Contains 1 B box-type zinc finger.

Contains 1 RanBP2-type zinc finger.

Contains 1 RING-type zinc finger.

Contains 1 ubiquitin-like domain.


Gene ID:

10616

RBCK1/HBV associated factor 4抗体antibody, Ab)是由效应B细胞(效应**B细胞)分泌,机体用于抵御外来物质,如病毒,**等抗原,结构呈“Y”字型的球状蛋白质,仅仅存在于脊椎动物的血液和B**细胞膜表面。凡是能够跟抗体结合的物质,均被称作抗原,因此对于抗抗体(能够结合抗体的抗体)来说,抗体本身也是一种抗原物质。

   QQ图片20171030091318

RBCK1/HBV associated factor 4抗体普通抗体重链和轻链的结构

重链结构:普通的**球蛋白具有2条重链(H链),分子量约为50kD,有μ、δ、γ、ε和α五种重链亚型,对应的**球蛋白名称分别为IgMIgGIgAIgDIgE

轻链结构:  普通**球蛋白具有2条轻链(L链),分子质量约25kDa,有κ链和λ链两种亚型,这两种轻链决定了Ig的亚型类别(IgG1IgG2IgG3IgG4)。一个天然的Ig分子两条轻链总是相同的,但在同一个体内可存在分别带有κ或λ链的抗体分子。不同种属生物体内两型轻链的比例不同,正常人血清**球蛋白κ链:λ链约为21,而在小鼠的比例为201

2.2抗体Fab段和Fc

IgG经木瓜蛋白酶酶切后裂解为2个完全相同的Fab段和1Fc,每个Fab段都为单价,可与抗原结合但不会再发生凝集反应;经胃蛋白酶酶切后裂解为1个完整F(ab)2片段和碎片化的Fc片段,F(ab)2片段为双价,可同时结合两个抗原表位。Fab段为抗原结合片段(fragment of antigen bindingFab),相当于抗体分子的两个臂,由一个完整的轻链和重链的VHCH1结构域组成。Fc段为可结晶段(fragment crystallizableFc)相当于IgCH2CH3结构域,是Ig与效应分子或者细胞相互作用的部位。Fab段包含完整的可变区,以及恒定区的CH1区域。Fc段仅指Ig恒定区CH2CH3的区域,相当于Y字结构下面那一部分。

合格 KCTD19 钾离子通道多聚体结构域蛋白19抗体
合格 KCTD6 KCTD6蛋白抗体
合格 合格 KCTD9 KCTD9蛋白抗体
合格 CANX 钙连蛋白抗体
合格 KDM6A 组蛋白去甲基化酶UTX抗体
合格 DcR2 诱捕受体2抗体
合格 Keratin 80 细胞角蛋白80抗体
合格 KGFLP1 成纤维细胞生长因子样蛋白1抗体
合格 BCOX1 乳腺癌过表达基因1蛋白抗体
合格 DELE DELE蛋白抗体
合格 DR5 肿瘤细胞调亡素/死亡受体5抗体
合格 KIAA0427 KIAA0427蛋白抗体
合格 KIAA0513 KIAA0513蛋白抗体
合格 KIAA0556 KIAA0556蛋白抗体
合格 KIAA0649 KIAA0649蛋白抗体
合格 DEFA1/alpha Defensin 1 防御素α1/3抗体
合格 KIAA0748 KIAA0748蛋白抗体
合格 KIAA0859 KIAA0859蛋白抗体
合格 KIAA0907 KIAA0907蛋白抗体
合格 合格 KIAA1024 KIAA1024蛋白抗体
合格 KIAA1143 KIAA1143蛋白抗体
合格 KIAA1161 KIAA1161蛋白抗体
合格 KIAA1211 KIAA1211蛋白抗体
合格 KIAA1276 KIAA1276蛋白抗体
合格 KIAA1310 KIAA1310蛋白抗体
合格 Keratin 36 细胞角蛋白36抗体
 


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