凋亡细胞**受体抗体
规格：1mg/1ml
英文名： JMJD6
别名： Apoptotic cell clearance receptor; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; JMJD 6; JMJD6; JMJD6_HUMAN; Jumo
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human JMJD6
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Zebrafish
细胞定位：细胞核
凋亡细胞**受体抗体产品介绍：background: This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for 凋亡细胞**受体抗体angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses. Subunit: Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65. Subcellular Location: Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. Tissue Specificity: Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. Similarity: Belongs to the JMJD6 family. Contains 1 JmjC domain.凋亡细胞**受体抗体 Gene ID: 23210 Database links: Entrez Gene: 417355 Chicken Entrez Gene: 508343 Cow Entrez Gene: 23210 Human Entrez Gene: 107817 Mouse Entrez Gene: 360665 Rat Entrez Gene: 266962 Zebrafish Omim: 604914 Human SwissProt: Q5ZMK5 Chicken SwissProt: Q58DS6 Cow SwissProt: Q6NYC1 Human SwissProt: Q9ERI5 Mouse SwissProt: Q5R6G2 Orangutan SwissProt: Q6AYK2 Rat SwissProt: Q6PFM0 Zebrafish Unigene: 514505 Human Unigene: 383423 Mouse Unigene: 19923 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
凋亡细胞**受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 干细胞 细胞凋亡 转录调节因子 细胞表面分子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid