癌/睾丸抗原58抗体
规格：1mg/1ml
英文名： NALP4
别名： Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; Cancer/testis antigen 58; CLR19.5; CT58; NACHT, leucine rich repeat and PYD containing 4; NACHT, LRR and P
分子量： 113kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NALP4
交叉反应：Human, Mouse, Rat, Pig, Horse,
细胞定位：
癌/睾丸抗原58抗体产品介绍：background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]. Function: May be involved in inflammation. Acts as a negative regulator癌/睾丸抗原58抗体 of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 8 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Gene ID: 147945 Database links: Entrez Gene: 147945 Human Entrez Gene: 499069 Rat Omim: 609645 Human SwissProt癌/睾丸抗原58抗体: Q96MN2 Human Unigene: 631533 Human Unigene: 222403 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：癌/睾丸抗原58抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid