富含亮氨酸重复结构域蛋白7抗体
规格：1mg/1ml
英文名： NLRP7
别名： CLR19.4; FLJ94610; HYDM; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains containing protein 7; NACHT, LRR and PYD domains-containin
分子量： 108kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NLRP7
交叉反应：Human,
细胞定位：
富含亮氨酸重复结构域蛋白7抗体产品介绍：background: This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: Inhibits CASP1/caspase-1-dependent IL1B secretion. Subunit: Directly interacts with CASP1 and IL1B. Tissue Specificity: Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle. DISEASE: Defects in NLRP7 are the cause of hydatidiform mole recurrent type 1 富含亮氨酸重复结构域蛋白7抗体(HYDM1) [MIM:231090]. A disorder characterized by excessive trophoblast development and the presence of a growing mass of tissue inside the uterus at the beginning of a pregnancy. It leads to abnormal pregnancies with no embryo, and cystic degeneration of the chorionic villi. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT 富含亮氨酸重复结构域蛋白7抗体domain. Gene ID: 199713 Database links: Entrez Gene: 199713 Human Omim: 609661 Human SwissProt: Q8WX94 Human Unigene: 351118 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含亮氨酸重复结构域蛋白7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid