周期素M2抗体
规格：1mg/1ml
英文名： Cyclin M2
别名： ACDP2; Ancient conserved domain containing protein 2; Ancient conserved domain protein 2; Ancient conserved domain-containing protein 2; CNNM 2; CNNM2; CNNM2_HUMAN; Cyclin M2; Cyclin-M2; Metal transpo
分子量： 96kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cyclin M
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞膜
周期素M2抗体产品介绍：background: Cyclin M2, also known as CNNM2 or ACDP2 (ancient conserved domain-containing protein 2), is an 875 amino acid multi-pass membrane protein that contains two CBS domains and belongs to the ACDP family. Expressed in a variety of tissues with highest expression in placenta, brain and kidney, cyclin M2 functions as a divalent metal cation transporter that mediates the transport of several different metal cations, including Mg2+, Co2+ and Fe2+. Cyclin M2 exists as multiple alternatively spliced isoforms and, contrary to its name, exhibits no cyclin-like function in vivo. The gene encoding cyclin M2 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. Function: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+ Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely周期素M2抗体expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop. DISEASE: Defects in CNNM2 are the cause of hypomagnesemia type 6 (HOMG6) [MIM:613882]. A renal disease characterized by severely lowered serum magnesium levels in the absence of other electrolyte disturbances. Affected individuals show an inappropriately normal urinary magnesium excretion, demonstrating a defect in tubular reabsorption. Age of clinical onset is highly variable and some affected individuals are asymptomatic. Similarity: Belongs to the ACDP family. Contains 2 CBS domains. Contains 1 DUF21周期素M2抗体 domain. Database links: Entrez Gene: 54805 Human Entrez Gene: 94219 Mouse Entrez Gene: 294014 Rat Omim: 607803 Human SwissProt: Q9H8M5 Human SwissProt: Q3TWN3 Mouse SwissProt: Q5U2P1 Rat Unigene: 643509 Human Unigene: 657970 Human Unigene: 306903 Mouse Unigene: 205139 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
周期素M2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 细胞周期蛋白 通道蛋白 细胞膜受体 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid