核突触蛋白β/β synuclein抗体
规格：1mg/1ml
英文名： Beta-synuclein
别名： beta Synuclein; Phosphoneuroprotein 14; Beta-synuclein; PNP14; SNCB; Synuclein beta; SYUB_HUMAN.
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human beta Syn
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞浆
核突触蛋白β/β synuclein抗体产品介绍：background: The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by 核突触蛋白β/β synuclein抗体RefSeq, Jul 2008]. Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed predominantly in brain; concentrated in 核突触蛋白β/β synuclein抗体presynaptic nerve terminals. Similarity: Belongs to the synuclein family. Gene ID: 6620 Database links: Entrez Gene: 6620 Human Entrez Gene: 104069 Mouse Entrez Gene: 113893 Rat Omim: 602569 Human SwissProt: Q16143 Human SwissProt: Q91ZZ3 Mouse SwissProt: Q63754 Rat Unigene: 90297 Human Unigene: 200843 Mouse Unigene: 20352 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核突触蛋白β/β synuclein抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid