myocardin相关转录因子抗体
规格：1mg/1ml
英文名： Mkl1
别名： AMKL; Bsac; Mal; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; MKL (megakaryoblastic leukemia)/myocardin like 1; MKL/myocardin like protein 1; MKL/myocardin-like protein
分子量： 45, 90kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Mkl1/MRT
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow,
细胞定位：细胞核 细胞浆
myocardin相关转录因子抗体产品介绍：background: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation. Function: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation (By similarity). Subunit: Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2. Subcellular Location: myocardin相关转录因子抗体Cytoplasm. Nucleus. Binding to globular actin is required to maintain cytoplasmic localization. Tissue Specificity: Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain. DISEASE: Note=A chromosomal aberration involving MKL1 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with RBM15. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimericmyocardin相关转录因子抗体 protein has all the putative functional domains encoded by each gene and is the candidate oncogene. Similarity: Contains 2 RPEL repeats. Contains 1 SAP domain. Gene ID: 57591 Database links: UniProtKB/Swiss-Prot: Q969V6.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
myocardin相关转录因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 细胞凋亡 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid