Noxa蛋白抗体
规格：1mg/1ml
英文名： Noxa
别名： Adult T cell leukemia derived PMA responsive; APR; APR_HUMAN; Immediate early response protein APR; Immediate-early-response protein APR; Phorbol 12 myristate 13 acetate induced protein 1; Phorbol-12-
分子量： 6kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Noxa
交叉反应：Human, Mouse, Rat, Pig, Horse,
细胞定位：细胞浆 线粒体
Noxa蛋白抗体产品介绍：background: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Function: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Noxa蛋白抗体Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Subunit: Interacts with MCL1, BCL2A1 and BAX. Subcellular Location: Noxa蛋白抗体Mitochondrion. Tissue Specificity: Highly expressed in ***** T-cell leukemia cell line. Similarity: Belongs to the PMAIP1 family. Database links: UniProtKB/Swiss-Prot: Q13794.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Noxa蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞凋亡 线粒体
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid