核凋亡因子THAP1抗体
规格：1mg/1ml
英文名： THAP1
别名： Nuclear proapoptotic factor; THAP 1; THAP domain containing apoptosis associated protein 1; THAP domain containing protein 1; THAP domain protein 1; THAP1_HUMAN.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human THAP1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞核
核凋亡因子THAP1抗体产品介绍：background: THAP1 contains a THAP domain, a zinc-dependent DNA-binding domain. It colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies and is a pro-apoptopic protein that potentiates both serum-withdrawal and TNF-induced apoptosis. It is a physiologic regulator of endothelial cell proliferation and cell-cycle progression, two essential processes for angiogenesis. Function: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Subunit: Interacts with PAWR.核凋亡因子THAP1抗体 Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter. Subcellular Location: Nucleus, nucleoplasm. Nucleus, PML body. Tissue Specificity: Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. DISEASE: Defects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by核凋亡因子THAP1抗体 onset in early *****hood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions. Similarity: Belongs to the THAP1 family. Contains 1 THAP-type zinc finger. Gene ID: 55145 Database links: Entrez Gene: 55145 Human Omim: 609520 Human SwissProt: Q9NVV9 Human Unigene: 7432 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核凋亡因子THAP1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 信号转导 细胞凋亡 细胞周期蛋白
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid