FEM1B抗体
规格：1mg/1ml
英文名： FEM 1B
别名： F1A-alpha; F1AA; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; Fem1 homolog b; FEM1 like death receptor binding protein; FEM1-beta; FEM1B; FEM1B_HUMAN
分子量： 70kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FEM 1B
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
FEM1B抗体产品介绍：background: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues. Function: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to theFEM1B抗体 activation of CHEK1. Subunit: Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1. Subcellular Location: Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin. Tissue Specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues. Similarity: Belongs to the fem-1 family.FEM1B抗体 Contains 8 ANK repeats. Contains 1 TPR repeat. Gene ID: 10116 Database links: Entrez Gene: 10116 Human Entrez Gene: 14155 Mouse Entrez Gene: 315745 Rat Omim: 613539 Human SwissProt: Q9UK73 Human SwissProt: Q9Z2G0 Mouse SwissProt: P0C6P7 Rat Unigene: 362733 Human Unigene: 24069 Mouse Unigene: 219320 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FEM1B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞凋亡
储存条件：
来源： Rabbit
外观： Lyophilized or Liquid