血管生长因子VG5Q抗体
规格：1mg/1ml
英文名： VG5Q
别名： AGGF 1; AGGF-1; Angiogenic factor VG5Q; Angiogenic factor with G patch and FHA domains 1; FLJ10283; G patch domain containing protein 7; GPATC 7; GPATC7; GPATCH 7; GPATCH7; HSU84971; HUS84971; hVG5Q;
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VG5Q/AGG
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞浆 分泌型蛋白
血管生长因子VG5Q抗体产品介绍：background: Angiogenic factors are critical to the initiation of angiogenesis and maintenance of the vascular network. VG5Q protein acts as a potent angiogenic factor in promoting angiogenesis, and suppression of VG5Q expression inhibits vessel formation. VG5Q shows strong expression in blood vessels and is secreted as vessel formation is initiated. VG5Q can bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. It also interacts with another secreted angiogenic factor, TWEAK (also known as TNFSF12). VG5Q is defective in patients with the vascular disease Klippel-Trenaunay syndrome (KTS). Function: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Subunit: Interacts with the secreted angiogenic factor TNFSF12. Subcellular Location: Cytoplasm. Secreted. Note=Cytoplasmic 血管生长因子VG5Q抗体in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted. Tissue Specificity: Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells. DISEASE: Defects in AGGF1 are a cause of Klippel-Trenaunay syndrome (KTS) [MIM:149000]. KTS is a congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft 血管生长因子VG5Q抗体tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. Similarity: Contains 1 FHA domain. Contains 1 G-patch domain. Database links: UniProtKB/Swiss-Prot: Q8N302.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血管生长因子VG5Q抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 生长因子和** 血管内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid