抑制蛋白结构域蛋白3抗体
规格：1mg/1ml
英文名： ARRDC3
别名： ARRDC 3; Arrestin domain containing protein 3; KIAA1376; Thioredoxin binding protein 2 like inducible membrane; TLIMP; ARRD3_HUMAN.
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ARRDC3 c
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
抑制蛋白结构域蛋白3抗体产品介绍：background: The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs). In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors and can directly 抑制蛋白结构域蛋白3抗体activate signaling pathways on their own. Different arrestins (visual arrestin (or Arrestin 1), beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways. Subunit: Does not bind TXN (thioredoxin). Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in skeletal muscle, placenta, kidney, adrenal gland,抑制蛋白结构域蛋白3抗体 lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes. Similarity: Belongs to the arrestin family. Database links: UniProtKB/Swiss-Prot: Q96B67.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
抑制蛋白结构域蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid