RB1的诱导卷曲蛋白RB1CC1抗体
规格：1mg/1ml
英文名： RB1CC1/FIP200
别名： CC1; CG1347; CG1347-PA isoform A; CG1347-PB isoform B; DRAGOU14; KIAA0203; RB1 inducible coiled coil 1; RB1-inducible coiled-coil protein 1; RB1CC1; RBCC1_HUMAN; FAK family kinase-interacting protein
分子量： 183kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RB1CC1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆 细胞膜
RB1的诱导卷曲蛋白RB1CC1抗体产品介绍：background: The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]. Function: Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Involved in autophagy. Required for autophagosome formation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstreamRB1的诱导卷曲蛋白RB1CC1抗体 signaling pathways. Subunit: Part of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1. This complex associates with ATG101. Interacts with PTK2/FAK1 and PTK2B/PYK2. Subcellular Location: Nucleus. Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. Tissue Specificity: Expression levels correlated closely with those RB1的诱导卷曲蛋白RB1CC1抗体of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. Database links: UniProtKB/Swiss-Prot: Q8TDY2.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RB1的诱导卷曲蛋白RB1CC1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid