钾离子通道多聚体结构域蛋白12抗体
规格：1mg/1ml
英文名： KCTD12
别名： C13orf2; BTB/POZ domain-containing protein KCTD12; C13orf2; KCD12_HUMAN; KCTD12; KIAA1778; PFET1; Pfetin; potassium channel tetramerisation domain containing 12 USA; Predominantly fetal expressed T1 d
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCTD12 (
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
钾离子通道多聚体结构域蛋白12抗体产品介绍：background: The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (POxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. KCTD12 (potassium channel tetramerisation domain containing 12), also known as PFET1 or PFETIN, is a 325 amino acid protein that is expressed in fetal organs, with highest levels in the cochlea and brain and extremely low levels in ***** organs, such as brain and lung. KCTD12 is considered a prognostic biomarker of gastrointestinal stromal tumors. Function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors钾离子通道多聚体结构域蛋白12抗体 by accelerating onset and promoting desensitization. Subcellular Location: Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse > postsynaptic cell membrane. Tissue Specificity: Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in ***** organs, such as brain and lung.钾离子通道多聚体结构域蛋白12抗体 Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Database links: UniProtKB/Swiss-Prot: Q96CX2.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钾离子通道多聚体结构域蛋白12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid