AlkB同源蛋白7抗体
规格：1mg/1ml
英文名： ALKBH7
别名： ABH7; ALKB7_HUMAN; ALKBH7; Alkylated DNA repair protein alkB homolog 7; MGC10974; Probable alpha-ketoglutarate-dependent dioxygenase ABH7; SPATA11; Spermatogenesis cell proliferation-related protein;
分子量： 22kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ALKBH7
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
AlkB同源蛋白7抗体产品介绍：background: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Function: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). AlkB同源蛋白7抗体Subcellular Location: Cytoplasm. Nucleus. Secreted. Has a predicted N-terminal signal sequence, indicating it may be secreted. Detected in cytoplasm and nucleus when expressed as fusion protein with an N-terminal tag. Tissue Specificity: Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. Similarity: Belongs to the alkB family. Gene ID: 84266 Database links:AlkB同源蛋白7抗体 Entrez Gene: 84266 Human Omim: 613305 Human SwissProt: Q2M2S8 Cow SwissProt: Q9BT30 Human Unigene: 111099 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AlkB同源蛋白7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid