囊泡谷氨酸转运蛋白3抗体
规格：1mg/1ml
英文名： VGLUT3/SLC17A8
别名： deafness autosomal dominant 25; DFNA 25; DFNA25; SLC17A8; Solute carrier family 17 (sodium dependent inorganic phosphate cotransporter) member 8; Solute carrier family 17 member 8; Vesicular glutamate
分子量： 65kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VGLUT3/S
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
囊泡谷氨酸转运蛋白3抗体产品介绍：background: This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Subcellular Location: Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Membrane. Cell junction > synapse > synaptosome. Tissue Specificity: Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus. 囊泡谷氨酸转运蛋白3抗体DISEASE: Defects in SLC17A8 are the cause of deafness autosomal dominant type 25 (DFNA25) [MIM:605583]. DFNA25 is a form of sensorineural hearing loss. The expression of DFNA25 deafness is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged. Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. Gene ID: 246213 Database 囊泡谷氨酸转运蛋白3抗体links: Entrez Gene: 246213 Human Entrez Gene: 216227 Mouse Entrez Gene: 266767 Rat Omim: 607557 Human SwissProt: Q8NDX2 Human SwissProt: Q8BFU8 Mouse SwissProt: Q7TSF2 Rat Unigene: 116871 Human Unigene: 233921 Mouse Unigene: 84876 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
囊泡谷氨酸转运蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid