亨丁顿舞蹈症相互作用蛋白12/HIP1R抗体
规格：1mg/1ml
英文名： HIP12
别名： Hip1 related; HIP12; HIP3; Huntingtin Interacting Protein 1 Related; HIP1R; Huntingtin interacting protein 12; HIP1R_HUMAN.
分子量： 119kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HIP1R/HI
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞浆 细胞膜
亨丁顿舞蹈症相互作用蛋白12/HIP1R抗体产品介绍：background: Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1. Function: Component of clathrin-coated pits and vesicles, that may link the亨丁顿舞蹈症相互作用蛋白12/HIP1R抗体 endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. Subunit: Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1. Homodimer. Homodimerization promotes actin binding. Subcellular Location: Cytoplasm, perinuclear region. Intracytoplasmic membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region. Tissue Specificity: Brain, heart, kidney, pancreas, 亨丁顿舞蹈症相互作用蛋白12/HIP1R抗体and liver, but not in lung or placenta. Similarity: Belongs to the SLA2 family. Contains 1 ENTH (epsin N-terminal homology) domain. Contains 1 I/LWEQ domain. Database links: Entrez Gene: 9026 Human Entrez Gene: 29816 Mouse Entrez Gene: 81917 Rat Omim: 605613 Human SwissProt: O75146 Human SwissProt: Q9JKY5 Mouse Unigene: 524815 Human Unigene: 714965 Human Unigene: 149954 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
亨丁顿舞蹈症相互作用蛋白12/HIP1R抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid