蛋白酪氨酸磷酸酶H1抗体
规格：1mg/1ml
英文名： PTPH1
别名： cytoskeletal-associated protein tyrosine phosphatase; protein tyrosine phosphatase H1; protein tyrosine phosphatase non-receptor type 3; Protein-tyrosine phosphatase H1; PTN3_HUMAN; PTP H1; PTP-H1; PT
分子量： 104kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTPH1/PT
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
蛋白酪氨酸磷酸酶H1抗体产品介绍：background: The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. PTP-H1 shares homology with the cytoskeletal-associated proteins band 4.1, ezrin, and talin and has been shown to contain a PDZ and band 4.1 domain. These domains are responsible for targeting proteins to the cytoskeleton-membrane interface, as well as mediating protein-protein interactions, recognizing C-terminal valine residues and binding to other PDZ domains. Overexpression of PTP-H1 may蛋白酪氨酸磷酸酶H1抗体 reverse transformation induced by oncogenic protein-tyrosine kinases, such as the members of the src family. Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Subcellular Location: Cell membrane. Cytoplasm. cytoskeleton. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM 蛋白酪氨酸磷酸酶H1抗体domain. Contains 1 PDZ (DHR) domain. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 5774 Database links: Entrez Gene: 5774 Human Entrez Gene: 545622 Mouse Omim: 176877 Human SwissProt: P26045 Human SwissProt: A2ALK8 Mouse Unigene: 436429 Human Unigene: 246552 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酪氨酸磷酸酶H1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 激酶和磷酸酶 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid