丝氨酸/苏氨酸蛋白激酶TNN13K抗体
规格：1mg/1ml
英文名： TNNI3K
别名： Cardiac ankyrin repeat kinase; CARK; MGC142099; MGC33828; Serine/threonine protein kinase TNN13K; Serine/threonine-protein kinase TNNI3K; TNI3K_HUMAN; TNNI3 interacting kinase; TNNI3-interacting kinas
分子量： 93kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNNI3K
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
丝氨酸/苏氨酸蛋白激酶TNN13K抗体产品介绍：background: TNNI3K, also known as CARK, is a 936 amino acid serine/threonine-protein kinase that is highly expressed in heart. Overexpression of TNNI3K leads to improved cardiac function by enhancing beating frequency and increasing contractile force and epinephrine response. TNNI3K suppresses phosphorylation of cardiac troponin I and p38/JNK-mediated apoptosis, therefore protecting the myocardium from ischemic injury. Administration of TNNI3K to mice with myocardial infarction improves cardiac performance and attentuates ventricular remodeling, suggesting that TNNI3K could be a promising target in the treatment of cardiac diseases. There are four isoforms of TNNI3K that are produced as a result of alternative splicing events. Function: May play a role in cardiac physiology. Subunit: Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB. Subcellular Location: Nucleus. Cytoplasm. Expressed at丝氨酸/苏氨酸蛋白激酶TNN13K抗体 lower levels in the cytoplasm. Tissue Specificity: Highly expressed in both ***** and fetal heart. Post-translational modifications: Autophosphorylated. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 10 ANK repeats. Contains 1 protein kinase domain. Database links: Entrez Gene: 100526835 Human Entrez Gene: 丝氨酸/苏氨酸蛋白激酶TNN13K抗体51086 Human Entrez Gene: 435766 Mouse Entrez Gene: 295531 Rat SwissProt: Q59H18 Human SwissProt: Q5GIG6 Mouse SwissProt: Q7TQP6 Rat Unigene: 729320 Human Unigene: 210428 Mouse Unigene: 3434 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸/苏氨酸蛋白激酶TNN13K抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid