9号染色体开放阅读框46抗体
规格：1mg/1ml
英文名： C9ORF46
别名： FLJ14688; AD025; Chromosome 9 open reading frame 46; FLJ39176; Hypothetical protein LOC55848; MDS030; transmembrane protein C9orf46; Uncharacterized hematopoietic stem/progenitor cells protein MDS030;
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C9ORF46
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜 细胞外基质
9号染色体开放阅读框46抗体产品介绍：background: C9orf46 is a 147 amino acid transmembrane protein. The gene encoding C9orf46 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. Function: Receptor for plasminogen.9号染色体开放阅读框46抗体 Regulates urokinaseplasminogen activator-dependent and stimulates tissue-typeplasminogen activator-dependent cell surface plasminogenactivation. Proposed to be part of a local catecholaminergic cellplasminogen activation system that regulates neuroendocrineprohormone processing. Involved in regulation of inflammatoryresponse; regulates monocyte chemotactic migration and matrixmetallproteinase activation, such as of MMP2 and MMP9. Subunit: Interacts with PLAT and PLAUR (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein.Note=Colocalizes on the cell surface with urokinase plasminogenactivator surface receptor/PLAUR (By similarity). Tissue Specificity: 9号染色体开放阅读框46抗体Expressed in peripheral blood cells andmonocytes. Expressed in adrenal medulla. Database links: Entrez Gene: 55848 Human SwissProt: Q9HBL7 Human SwissProt: Q9D3P8 Mouse Unigene: 584242 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
9号染色体开放阅读框46抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid