肌动蛋白依赖染色质调控因子SMARCD3蛋白抗体
规格：1mg/1ml
英文名： SMARCD3
别名： 60 kDa BRG 1/Brm associated factor subunit C; 60 kDa BRG-1/Brm-associated factor subunit C; BAF60C; BRG1 associated factor 60C; BRG1-associated factor 60C; CRACD3; MGC111010; Rsc6p; Smarcd3; SMRD3_HUM
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SMARCD3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Sheep,
细胞定位：细胞核
肌动蛋白依赖染色质调控因子SMARCD3蛋白抗体产品介绍：background: SMARCD3, is a member of the SMARCD family and contains one SWIB domain. Two isoforms, isoform 1 and isoform 2 exist due to alternative splicing events. Both isoforms are expressed in placenta, salivary gland, kidney, brain, trachea, uterus, prostate, testis, thyroid, spleen and heart, while isoform 1 is also expressed in adipose tissue and skeletal muscle. Localizing to the nucleus, SMARCD3 is a component of the ATP-dependent chromatin remodeling complex SNF/SWI and is believed to play a role in nucleosome remodeling. SMARCD3 also plays an important role in the regulation of muscle development. In mice, the silencing of the gene en-coding SMARCD3 leads to defects in heart morphogenesis. In addition, both isoforms of SMARCD3 directly interact with and function as coactivators for several transcription factors. Function: Plays a role in ATP dependent nucleosome remodeling bySMARCA4 containing complexes. Stimulates nuclear receptor mediatedtranscription. Belongs to the neural progenitors-specific chromatinremodeling complex (npBAF complex) and the neuron-specificchromatin remodeling complex (nBAF complex). During neuraldevelopment a switch from a stem/progenitor to a post-mitoticchromatin remodeling mechanism occurs as neurons exit the cellcycle and become committed to their ***** state. The transitionfrom proliferating neural stem/progenitor cells to post-mitoticneurons requires a switch in subunit composition of the npBAF andnBAF complexes. As neural progenitors exit mitosis anddifferentiate into neurons, npBAF complexes which containACTL6A/BAF53A and PHF10/BAF45A, are exchanged for肌动蛋白依赖染色质调控因子SMARCD3蛋白抗体 homologousalternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunitsin neuron-specific complexes (nBAF). The npBAF complex is essentialfor the self-renewal/proliferative capacity of the multipotentneural stem cells. The nBAF complex along with CREST plays a roleregulating the activity of genes essential for dendrite growth (Bysimilarity). Subunit: Component of the BAF complex, which includes at leastactin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A,ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155,SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more ofSMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells,the BAF complex also contains DPF3. Interacts withSMARCA4/BRG1/BAF190A, the catalytic subunit of the SWI/SNF relatednucleosome-remodeling complexes BRG1(I) and BRG1(II). The precisedistribution of the related SMARCD1, SMARCD2 and SMARCD3 proteinsamong these and other SWI/SNF nucleosome-remodeling complexes isnot fully known. Also interacts with several nuclear receptorsincluding PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 andother transcriptional activators including the HLH proteinSREBF1/SREBP1 and the homeobox protein PBX1. 肌动蛋白依赖染色质调控因子SMARCD3蛋白抗体May allow recruitmentof Swi/SNF containing complexes specifically to promoters wherethese factors are located. Component of neural progenitors-specificchromatin remodeling complex (npBAF complex) composed of at least,ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A,ACTL6A/BAF53A and actin. Component of neuron-specific chromatinremodeling complex (nBAF complex) composed of at least,ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B,DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue. Similarity: Belongs to the SMARCD family. Contains 1 SWIB domain. Gene ID: 6604 Database links: Entrez Gene: 6604 Human Entrez Gene: 66993 Mouse Entrez Gene: 296732 Rat Omim: 601737 Human SwissProt: Q6STE5 Human SwissProt: Q6P9Z1 Mouse Unigene: 647067 Human Unigene: 436539 Mouse Unigene: 20043 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌动蛋白依赖染色质调控因子SMARCD3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 染色质和核信号 神经生物学 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid