心肌病相关蛋白2抗体
规格：1mg/1ml
英文名： CMYA2/PDE4DIP
别名： Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; Phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting prot
分子量： 265kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CMYA2/PD
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
心肌病相关蛋白2抗体产品介绍：background: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and ***** heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events. Function: May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity). 心肌病相关蛋白2抗体Subunit: Interacts with PDE4D (By similarity). Subcellular Location: Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta. DISEASE: Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein. Similarity: Contains 1 NBPF domain. Database links: Entrez Gene:心肌病相关蛋白2抗体 9659 Human Entrez Gene: 83679 Mouse Entrez Gene: 64183 Rat Omim: 608117 Human SwissProt: Q5VU43 Human SwissProt: Q80YT7 Mouse SwissProt: Q9WUJ3 Rat Unigene: 584841 Human Unigene: 613082 Human Unigene: 657490 Human Unigene: 728768 Human Unigene: 129840 Mouse Unigene: 48693 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
心肌病相关蛋白2抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 信号转导 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid