促血管平滑肌细胞分化因子抗体
规格：1mg/1ml
英文名： Myocardin
别名： MYCD; MYCD_HUMAN; Myocardin; Myocd.
分子量： 103kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Myocardi
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
促血管平滑肌细胞分化因子抗体产品介绍：background: Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Function: Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Subunit: Homodimer. Interacts with 促血管平滑肌细胞分化因子抗体SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C. Subcellular Location: Nucleus. Tissue Specificity: Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle. Post-translational modifications: Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity. Similarity: Contains 3 RPEL repeats. Contains 1 SAP domain. Database links: Entrez Gene:促血管平滑肌细胞分化因子抗体 93649 Human Entrez Gene: 214384 Mouse Entrez Gene: 396571 Pig Entrez Gene: 246297 Rat Omim: 606127 Human SwissProt: Q8IZQ8 Human SwissProt: Q8VIM5 Mouse SwissProt: Q8R5I7 Rat Unigene: 567641 Human Unigene: 32257 Mouse Unigene: 163103 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
促血管平滑肌细胞分化因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid