内皮细胞活化蛋白受体/CD201抗体
规格：1mg/1ml
英文名： EPCR
别名： Activated protein C receptor; APC receptor; APCR; CCCA; CCD41; CD201 antigen; centrocyclin; Endothelial cell protein C receptor; MGC23024; PROCR; EPCR_HUMAN; CD201.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EPCR/CD2
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
内皮细胞活化蛋白受体/CD201抗体产品介绍：background: EPCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. It is an N glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. It is expressed strongly in the endothelial cells of arteries and veins in heart and lung. It is overexpressed in several human non-Pgp multidrug resistant (MDR) tumor cell lines. Whether and how anti-coagulant and anti-inflammatory functions of EPCR facilitate oncogenesis and/or drug resistance is unclear. Function: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in内皮细胞活化蛋白受体/CD201抗体 the protein C pathway controlling blood coagulation. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. Post-translational modifications: N-glycosylated. A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. Database links: Entrez Gene:内皮细胞活化蛋白受体/CD201抗体 10544 Human Omim: 600646 Human SwissProt: Q9UNN8 Human Unigene: 647450 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内皮细胞活化蛋白受体/CD201抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid