凝血因子9抗体
规格：1mg/1ml
英文名： Factor IX
别名： Christmas Disease; Christmas factor; Coagulant factor IX; Coagulation factor 9; Coagulation factor IX (plasma thromboplastic component); Coagulation factor IX; Coagulation factor IXa heavy chain; F9;
分子量： 26/47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Coagulat
交叉反应：Human, Mouse, Rat, Cow, Sheep,
细胞定位：分泌型蛋白
凝血因子9抗体产品介绍：background: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin, and factors X, IX, V, and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble fibrin clots and the promotion of platelet aggregation (1-3). Coagulation factor IX (plasma thromboplastic component, F9, F.IX, HEMB) is a vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor (3,4). Factor XIa mediated proteolytic cleavage of factor IX generates factor IXa, an active serine protease composed of a 145 amino acid light chain and a 236 amino acid catalytic heavy chain, linked through disulfide bonds (5). Genetic alterations at the Factor IX locus such as point mutations, insertions and deletions, can lead to hemophilia B, also known as Christmas disease (6). Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Subunit: Heterodimer凝血因子9抗体 of a light chain and a heavy chain; disulfide-linked. Subcellular Location: Secreted Tissue Specificity: Synthesized primarily in the liver and secreted in plasma Post-translational modifications: Activated by factor XIa, which excises the activation peptide. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. DISEASE: Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease. Defects in F9 are the cause of thrombophilia due to factor IX defect 凝血因子9抗体(THPH8) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis. Similarity: Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain. Database links: Entrez Gene: 2158 Human Omim: 300746 Human SwissProt: P00740 Human Unigene: 522798 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
凝血因子9抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid