7号染色体开放阅读框27抗体
规格：1mg/1ml
英文名： C7orf27
别名： BAAT 1; BAAT1; BRAT-1; brat1; BRAT1_HUMAN; BRCA1-associated ATM activator 1; BRCA1-associated protein required for ATM activation protein 1; BRCA1-associated protein required for ATM activation-1; C7o
分子量： 88kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BAAT1/C7
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
7号染色体开放阅读框27抗体产品介绍：Function: Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM. Subunit: Interacts with BRCA1 and ATM. Subcellular Location: Nucleus. Present at double strand breaks (DSBs) following ionizing radiation treatment. Tissue Specificity: Ubiquitously expressed. DISEASE: Defects in BRAT1 are the cause of rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL) [MIM:614498]. A lethal, neonatal, neurologic disorder characterized by episodic jerking that is apparent in utero, lack of psychomotor development, axial and limb rigidity, frequent multifocal seizures, and dysautonomia. At birth, affected individuals 7号染色体开放阅读框27抗体have small heads, overlapping cranial sutures, small or absent fontanels, and depressed frontal bones. Infants show poorly responsive focal jerks of the tongue, face and arms in a nearly continuous sequence throughout life. Similarity: Contains 2 HEAT repeats. Database links: Entrez Gene: 221927 Human Entrez Gene: 231841 Mouse SwissProt: Q6PJG6 Human SwissProt: Q8C3R1 Mouse SwissProt: 7号染色体开放阅读框27抗体D3ZUM1 Rat Unigene: 520623 Human Unigene: 271932 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
7号染色体开放阅读框27抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid