RNA结合蛋白20抗体
规格：1mg/1ml
英文名： RBM20
别名： Probable RNA-binding protein 20; Rbm20; RBM20_HUMAN; RNA-binding motif protein 20.
分子量： 134kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
免疫原：KLH conjugated synthetic peptide derived from human RBM20
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞核
RNA结合蛋白20抗体产品介绍：background: This gene encodes a protein that likely binds RNA. Mutations in this gene have been associated with familial dilated cardiomyopathy. [provided by RefSeq, Mar 2010] Function: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin). Subcellular Location: Nucleus (By similarity). Tissue Specificity: Expressed in the heart. DISEASE: Defects in RBM20 are the cause of cardiomyopathy dilated type 1DD (CMD1DD) [MIM:613172]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Similarity: Contains 1 RRM (RNA recognition motif) domain. Database links: Entrez Gene: 282996 Human Entrez Gene: RNA结合蛋白20抗体73713 Mouse Entrez Gene: 309544 Rat Omim: 613171 Human SwissProt: Q5T481 Human SwissProt: Q3UQS8 Mouse Unigene: 92105 Cow Unigene: 116630 Human Unigene: 726550 Human Unigene: 485879 Mouse Unigene: 21596 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Involvement in disease;Defects in RNA结合蛋白20抗体RBM20 are the cause of cardiomyopathy dilated type 1DD (CMD1DD). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
RNA结合蛋白20抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid