核转录因子25抗体
规格：1mg/1ml
英文名： Transcription factor 25
别名： FKSG26; hKIAA1049; NULP1; PRO2620; Hulp1; KIAA1049; Nuclear localized protein 1; Transcription factor 25 (basic helix loop helix); TCF25_HUMAN.
分子量： 77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Transcri
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
细胞定位：细胞核
核转录因子25抗体产品介绍：background: Transcription factor 25 acts as a transcriptional repressor. It has been shown to repress transcription of SRF in vitro and hence may play a role in heart development.Transcription factor 25, is a 676 amino acid protein that plays a role in cell death. A member of the TCF25 family, Nulp1 utilizes its C-terminus to mediate transcriptional repression of SRF in vitro, and interacts with XIAP. Nulp1 localizes primarily to the nucleus but is also found in cytosol. Widely expressed, Nulp1 is found at high levels in embryonic brain and ***** heart. The gene encoding Nulp1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's 核转录因子25抗体disease, which is a gastrointestinal inflammatory condition. Function: May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Subunit: Interacts with XIAP (By similarity). Subcellular Location: Nuclear. Note=Some staining in the cytosol. Tissue Specificity: In the embryo, widely expressed with highest levels in brain. In the *****, highest expression is found in the heart. Similarity: Belongs to the TCF25 family. Gene ID: 22980 Database links:核转录因子25抗体 Entrez Gene: 22980 Human Entrez Gene: 66855 Mouse Omim: 612326 Human SwissProt: Q9BQ70 Human SwissProt: Q8R3L2 Mouse Unigene: 415342 Human Unigene: 178818 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核转录因子25抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid