JWA蛋白抗体
规格：1mg/1ml
英文名： JWA
别名： Addicsin; ADP ribosylation like factor 6 interacting protein 5; Aip 5; Aip5; ARL 6 interacting protein 5; ARL6IP5 antibody Cytoskeleton related vitamin A responsive protein; Dermal papilla derived pro
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human JWA
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
JWA蛋白抗体产品介绍：background: JWA is a four-transmembrane environmental responsive protein which binds to the CC chemokine recepor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV). JWA is involved in environmental stress-responsive pathways in K562 cells, an erythroleukemia cell line derived from patients with chronic myeloid leukemia. Environmental stressors to K562 cells such as heat shock, a higher temperature than the ideal body temperature of the organism from which the cell line was derived, and oxidative stress, the production of oxygen-centered free radicals, regulate and increase the expres-sion of JWA. This response to JWA蛋白抗体environmental stressors suggests similiarity of JWA to heat shock protein 70 (HSP70), which is upregulated by heat stress and toxic chemicals. Function: Regulates intracellular concentrations of taurine andglutamate. Negatively modulates SLC1A1/EAAC1 glutamate transportactivity by decreasing its affinity for glutamate. May be involvedin membrane traffic (By similarity). Subunit: Forms multimers. Binds to prenylated RAB1A and RAB3A, tothe neuronal glutamate transporter SLC1A1/EAAC1, and to theADP-ribosylation like factor ARL6, a member of the JWA蛋白抗体Ras superfamily.Does not bind to VAMP2 (By similarity). Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Associated with microtubules. Similarity: Belongs to the PRA1 family. Database links: Entrez Gene: 10550 Human Omim: 605709 Human SwissProt: O75915 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
JWA蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞周期蛋白 转录调节因子 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid