10号染色体开放阅读框63抗体
规格：1mg/1ml
英文名： C10orf63
别名： DKFZp781F21103; Chromosome 10 open reading frame 63; ENKUR; Enkurin; ENKUR_HUMAN.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C10orf63
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：
10号染色体开放阅读框63抗体产品介绍：background: Enkurin is a 256 amino acid adapter protein that brings signal transduction proteins and transient receptor potential canonical (TRPC) cation channels into contact. Localizing to the acrosomal crescent and flagellar principal piece of sperm, Enkurin contains one IQ domain which it uses to bind CaM (calmodulin). Enkurin is highly expressed in testis and vomeronasal organ, but is also found at lower levels in brain, ovary, heart and lung. The gene encoding Enkurin maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include 10号染色体开放阅读框63抗体Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10. Function: Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity). Subunit: Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity). Subcellular Location: Cell projection, cilium, flagellum. Note=Sperm acrosomal crescent and flagellar principal piece. Similarity: Contains 1 IQ domain. Database links: Entrez Gene: 219670 Human Entrez Gene: 10号染色体开放阅读框63抗体71233 Mouse GenBank: NM_145010 Human Omim: 611025 Human SwissProt: Q8TC29 Human SwissProt: Q6SP97 Mouse Unigene: 534486 Human Unigene: 27658 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产10号染色体开放阅读框63抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid