染色体相关蛋白CAP抗体
规格：1mg/1ml
英文名： CAP
别名： Brd4; BRD4_HUMAN; bromodomain containing protein 4; Bromodomain-containing protein 4; CAP; chromosome associated protein; HUNK1; Protein HUNK1.
分子量： 152kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Brd4/CAP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
染色体相关蛋白CAP抗体产品介绍：background: Brd4 belongs to the BET family, a group of structurally related proteins containing two bromodomains. Through these two domains, Brd4 associates with mitotic chromosomes and its expression correlates with cell growth. Expression of Brd4 inhibits cell cycle progression from G(1) to S, due to binding to the largest subunit of replication factor C (RFC) to prevent DNA elongation. Altered Brd4 function correlates with poorly differentiated carcinoma, with aggresive phenotype and a highly lethal outcome. Function: Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). Subunit: Associated with chromosomes during mitosis.染色体相关蛋白CAP抗体 Interacts with bovine papillomavirus type 1 regulatory protein E2. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed. DISEASE: Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein. Similarity: Contains 2染色体相关蛋白CAP抗体 bromo domains. Database links: Entrez Gene: 10487 Human Entrez Gene: 12331 Mouse Entrez Gene: 64185 Rat SwissProt: Q01518 Human SwissProt: P40124 Mouse SwissProt: Q08163 Rat Unigene: 370581 Human Unigene: 713078 Human Unigene: 8687 Mouse Unigene: 112585 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
染色体相关蛋白CAP抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid