2号染色体开放阅读框60抗体
规格：1mg/1ml
英文名： C2orf60
别名： Chromosome 2 open reading frame 60; FLJ37953; Hypothetical protein LOC129450; JmjC domain containing protein C2orf60; MGC70509; TYW5_HUMAN.
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C2orf60
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：
2号染色体开放阅读框60抗体产品介绍：background: C2orf60, also known as JmjC domain-containing protein C2orf60, FLJ37953 or MGC70509, is a 315 amino acid protein that exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 2q33.1. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result 2号染色体开放阅读框60抗体of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes. Function: tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4.2号染色体开放阅读框60抗体OHyW is a derivative of wybutosine found in higher eukaryotes. Subunit: Homodimer. Similarity: Belongs to the TYW5 family. Contains 1 JmjC domain. Database links: Entrez Gene: 129450 Human Entrez Gene: 68736 Mouse Entrez Gene: 301419 Rat SwissProt: A2RUC4 Human SwissProt: A2RSX7 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
2号染色体开放阅读框60抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid