氯离子通道调节蛋白1A抗体
规格：1mg/1ml
英文名： CLNS1A
别名： nucleotide sensitive 1A; Chloride channel; Chloride channel nucleotide sensitive 1A; Chloride channel regulatory protein; Chloride conductance regulatory protein ICln; Chloride ion current inducer pro
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CLNS1A/p
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
氯离子通道调节蛋白1A抗体产品介绍：background: The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved,氯离子通道调节蛋白1A抗体 ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1. Function: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Subunit: Homooligomer. Component of the methylosome, a 20S complex containing SKB1. Interacts with Sm proteins. Interacts with LSM10, LSM11 and SNRPB. 氯离子通道调节蛋白1A抗体Subcellular Location: Cytoplasm. Nucleus. Cytoplasm; cytoskeleton. A small fraction is also associated with the cytoskeleton. Similarity: Belongs to the pICln (TC 1.A.47) family. Database links: Entrez Gene: 1207 Human Omim: 602158 Human SwissProt: P54105 Human Unigene: 430733 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氯离子通道调节蛋白1A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid