糖蛋白VI/六糖蛋白抗体
规格：1mg/1ml
英文名： Glycoprotein VI
别名： Glycoprotein VI; GP6; GPIV; GPVI; MGC138168; Platelet collagen receptor; Platelet glycoprotein VI; Platelet glycoprotein VI precursor; GPVI_HUMAN.
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GPVI/Gly
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞膜
糖蛋白VI/六糖蛋白抗体产品介绍：background: Glycoprotein VI (GPVI) is a membrane glycoprotein receptor for collagen found in platelets. GPVI plays an important role in platelet procoagulant activity which may contribute to arterial and venous thrombus formation. GPVI is expressed in megakaryocytes and platelets. Patients deficient in GPVI suffer from mild hemorrhagic diathesis and their platelets fail to aggregate in response to collagen. There are three isoforms. Function: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Subunit: Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn. Subcellular Location: Cell Membrane; Single-pass membrane protein. Tissue Specificity: Megakaryocytes and platelets. 糖蛋白VI/六糖蛋白抗体Post-translational modifications: N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). DISEASE: Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11) [MIM:614201]. BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. Similarity: Contains 2 Ig-like C2-type 糖蛋白VI/六糖蛋白抗体(immunoglobulin-like) domains. Gene ID: 64115 Database links: Entrez Gene: 64115 Human Entrez Gene: 74048 Mouse SwissProt: Q9H7M9 Human SwissProt: Q9D659 Mouse Unigene: 47382 Human Unigene: 273584 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产糖蛋白VI/六糖蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid