抗肿瘤蛋白ANUP抗体
规格：1mg/1ml
英文名： ANUP
别名： Anti neoplastic urinary protein; ANUP; ARS; ARS component B; ARS(component B) 81/S; ArsB; LY6LS; Lymphocyte antigen 6 like secreted; MDM; Results in cobblestone changes in the skin of the palm; Secret
分子量： 9kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLURP1/A
交叉反应：Human,
细胞定位：分泌型蛋白
抗肿瘤蛋白ANUP抗体产品介绍：background: SLURP1, also known as MDM, ARS, ANUP (anti-neoplastic urinary protein), LY6LS or ArsB (ARS component B), is a 103 amino acid secreted protein that exists as a homodimer possessing antitumor activity. Found in esophagus, stomach, exocervix, gums, urine, sweat, saliva, plasma and tears, SLURP1 is most highly expressed in the acrosyringium of the granular layer of skin, where it helps maintain the structure of the keratinocyte layers of the skin. Also considered a marker for late skin differentiation, SLURP1 contains one UPAR/Ly6 domain and is the cause of an autosomal recessive disorder of the skin known as Mal de Meleda (MDM). MDM Is characterized by nail abnormalities, keratotic skin lesions, transgressive palmoplantar keratoderma (PPK), perioral erythema and may sometimes include hyperhidrosis. Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the 抗肿瘤蛋白ANUP抗体physiological and structural integrity of the keratinocyte layers of the skin. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine. DISEASE: Defects in SLURP1 are a cause of Mal de Meleda (MDM) [MIM:248300]; also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have 抗肿瘤蛋白ANUP抗体hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. Similarity: Contains 1 UPAR/Ly6 domain. Database links: Entrez Gene: 57152 Human Omim: 606119 Human SwissProt: P55000 Human Unigene: 103505 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
抗肿瘤蛋白ANUP抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid