19号染色体开放阅读框29抗体
规格：1mg/1ml
英文名： C19orf29
别名： C19orf29; Cactin; CS029_HUMAN; FLJ17482; FLJ59622; fSAPc; Renal carcinoma antigen NY-REN-24; Uncharacterized protein C19orf29.
分子量： 89kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cactin/C
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
细胞定位：细胞核
19号染色体开放阅读框29抗体产品介绍：background: Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The C19orf29 gene product has been provisionally designated C19orf29 pending further characterization. Function: Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor 19号染色体开放阅读框29抗体and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. Subunit: Interacts (via N-terminus domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex. Subcellular Location: Nucleus. Note=Nuclear localization19号染色体开放阅读框29抗体 with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. Similarity: Belongs to the CACTIN family. Database links: Entrez Gene: 58509 Human SwissProt: Q8WUQ7 Human SwissProt: Q9CS00 Mouse Unigene: 727616 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
19号染色体开放阅读框29抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 表观遗传学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid